Recent Trends in Macromolecule-conjugated Hybrid Quantum Dots for Cancer Theranostic Applications

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 Jun 22

PMID 37346950

Authors

Lokesh Kumar Boopathy

Thiyagarajan Gopal

Anitha Roy

Rakhee Rathnam Kalari Kandy

Madan Kumar Arumugam

Affiliations

Soon will be listed here.

Abstract

Quantum dots (QDs) are small nanoparticles with semiconductor properties ranging from 2 to 10 nanometers comprising 10-50 atoms. The single wavelength excitation character of QDs makes it more significant, as it can excite multiple particles in a confined surface simultaneously by narrow emission. QDs are more photostable than traditional organic dyes; however, when injected into tissues, whole animals, or ionic solutions, there is a significant loss of fluorescence. HQD-based probes conjugated with cancer-specific ligands, antibodies, or peptides are used in clinical diagnosis. It is more precise and reliable than standard immunohistochemistry (IHC) at minimal protein expression levels. Advanced clinical studies use photodynamic therapy (PDT) with fluorescence imaging to effectively identify and treat cancer. Recent studies revealed that a combination of unique characteristics of QDs, including their fluorescence capacity and abnormal expression of miRNA in cancer cells, were used for the detection and monitoring progression of cancer. In this review, we have highlighted the unique properties of QDs and the theranostic behavior of various macromolecule-conjugated HQDs leading to cancer treatment.

Citing Articles

Applicability of Quantum Dots in Breast Cancer Diagnostic and Therapeutic Modalities-A State-of-the-Art Review.

Kunachowicz D, Klosowska K, Sobczak N, Kepinska M Nanomaterials (Basel). 2024; 14(17).

PMID: 39269086 PMC: 11396817. DOI: 10.3390/nano14171424.

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