Risk of Drug Use During Pregnancy: Master Protocol for Living Systematic Reviews and Meta-analyses Performed in the MetaPreg Project

Overview

Journal Syst Rev

Publisher Biomed Central

Date 2023 Jun 21

PMID 37344917

Authors

Cyndie Picot

Priscilla Ajiji

Lucie Jurek

Mikail Nourredine

Jerome Massardier

Audrey Peron

Michel Cucherat

Judith Cottin

Affiliations

Soon will be listed here.

Abstract

Background: Knowledge about the risks of drugs during pregnancy is continuously evolving due to the frequent publication of a large number of epidemiological studies. Systematic reviews and meta-analyses therefore need to be regularly updated to reflect these advances. To improve dissemination of this updated information, we developed an initiative of real-time full-scale living meta-analyses relying on an open online dissemination platform ( www.metapreg.org ).

Method: All living meta-analyses performed in this project will be conducted in accordance with this master protocol after adaptation of the search strategy. A systematic literature search of PubMed and Embase will be performed. All analytical studies (e.g., cohort, case-control, randomized studies) reporting original empirical findings on the association between in utero exposure to drugs and adverse pregnancy outcomes will be included. Study screening and data extraction will be performed in a semi-automation way supervised by a biocurator. A risk of bias will be assessed using the ROBINS-I tools. All clinically relevant pregnancy adverse outcomes (malformations, stillbirths, neuro-developmental disorders, pre-eclampsia, etc.) available in the included studies will be pooled through random-effects meta-analysis. Heterogeneity will be evaluated by I statistics.

Discussion: Our living systematic reviews and subsequent updates will inform the medical, regulatory, and health policy communities as the news results evolve to guide decisions on the proper use of drugs during the pregnancy.

Systematic Review Registration: Open Science Framework (OSF) registries.

Citing Articles

Neurodevelopmental outcomes after prenatal exposure to lamotrigine monotherapy in women with epilepsy: a systematic review and meta-analysis.

Peron A, Picot C, Jurek L, Nourredine M, Ripoche E, Ajiji P BMC Pregnancy Childbirth. 2024; 24(1):103.

PMID: 38308208 PMC: 10835851. DOI: 10.1186/s12884-023-06242-9.

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