Olfactory Brain Activations in Patients with Major Depressive Disorder

Overview

Journal Sci Rep

Specialty Science

Date 2023 Jun 21

PMID 37344484

Authors

Theresa Herrmann

Carina Koeppel

Jennifer Linn

Ilona Croy

Thomas Hummel

Affiliations

Soon will be listed here.

Abstract

Depression is associated with reduced olfactory function. This relationship is assumed to be based on either a reduced olfactory bulb volume or diminished functioning of higher cortical areas. As previous results are controversial, we aimed to re-evaluate central olfactory processing in depression. We recorded the BOLD signal of 21 patients with Major Depressive Disorder and 21 age and gender matched healthy controls during odor presentation. In addition, we measured the individual olfactory bulb volume, tested odor identification and odor threshold, and asked for hedonic odor perception. In both groups, odor presentation led to a pronounced activation of primary olfactory areas. However, secondary olfactory areas were significantly less activated in depressed individuals. The two groups did not differ in olfactory bulb volume. Our results point towards altered olfactory processing in patients in those regions that relate to sensory integration and attention allocation. Difficulties in cognitive processing could impact olfactory function in depression. We are therefore in favor of a top-down mechanism originating in higher cortical areas explaining parts of the relation between depression and olfaction.

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References

Hedner M, Larsson M, Arnold N, Zucco G, Hummel T . Cognitive factors in odor detection, odor discrimination, and odor identification tasks. J Clin Exp Neuropsychol. 2010; 32(10):1062-7. DOI: 10.1080/13803391003683070. View

Hummel T, Sekinger B, Wolf S, Pauli E, Kobal G . 'Sniffin' sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses. 1997; 22(1):39-52. DOI: 10.1093/chemse/22.1.39. View

Negoias S, Croy I, Gerber J, Puschmann S, Petrowski K, Joraschky P . Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience. 2010; 169(1):415-21. DOI: 10.1016/j.neuroscience.2010.05.012. View

Yousem D, Geckle R, Bilker W, Doty R . Olfactory bulb and tract and temporal lobe volumes. Normative data across decades. Ann N Y Acad Sci. 1999; 855:546-55. DOI: 10.1111/j.1749-6632.1998.tb10624.x. View

Rombaux P, Duprez T, Hummel T . Olfactory bulb volume in the clinical assessment of olfactory dysfunction. Rhinology. 2009; 47(1):3-9. View

SNAITH R, Hamilton M, Morley S, Humayan A, Hargreaves D, Trigwell P . A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale. Br J Psychiatry. 1995; 167(1):99-103. DOI: 10.1192/bjp.167.1.99. View

Soudry Y, Lemogne C, Malinvaud D, Consoli S, Bonfils P . Olfactory system and emotion: common substrates. Eur Ann Otorhinolaryngol Head Neck Dis. 2011; 128(1):18-23. DOI: 10.1016/j.anorl.2010.09.007. View

Song C, Leonard B . The olfactory bulbectomised rat as a model of depression. Neurosci Biobehav Rev. 2005; 29(4-5):627-47. DOI: 10.1016/j.neubiorev.2005.03.010. View

Li W, Luxenberg E, Parrish T, Gottfried J . Learning to smell the roses: experience-dependent neural plasticity in human piriform and orbitofrontal cortices. Neuron. 2006; 52(6):1097-108. PMC: 1779760. DOI: 10.1016/j.neuron.2006.10.026. View

10.

Croy I, Hummel T . Olfaction as a marker for depression. J Neurol. 2016; 264(4):631-638. DOI: 10.1007/s00415-016-8227-8. View

11.

Mayberg H, Brannan S, Tekell J, Silva J, Mahurin R, McGinnis S . Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry. 2000; 48(8):830-43. DOI: 10.1016/s0006-3223(00)01036-2. View

12.

Lombion-Pouthier S, Vandel P, Nezelof S, Haffen E, Millot J . Odor perception in patients with mood disorders. J Affect Disord. 2005; 90(2-3):187-91. DOI: 10.1016/j.jad.2005.11.012. View

13.

Flohr E, Erwin E, Croy I, Hummel T . Sad man's nose: Emotion induction and olfactory perception. Emotion. 2016; 17(2):369-378. DOI: 10.1037/emo0000224. View

14.

Keller A, Leikauf J, Holt-Gosselin B, Staveland B, Williams L . Paying attention to attention in depression. Transl Psychiatry. 2019; 9(1):279. PMC: 6838308. DOI: 10.1038/s41398-019-0616-1. View

15.

Colle R, El Asmar K, Verstuyft C, Lledo P, Lazarini F, Chappell K . The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment. Psychol Med. 2020; :1-9. DOI: 10.1017/S0033291720003918. View

16.

Han P, Hummel T, Raue C, Croy I . Olfactory loss is associated with reduced hippocampal activation in response to emotional pictures. Neuroimage. 2018; 188:84-91. DOI: 10.1016/j.neuroimage.2018.12.004. View

17.

Wang Y, Gorenstein C . Psychometric properties of the Beck Depression Inventory-II: a comprehensive review. Braz J Psychiatry. 2014; 35(4):416-31. DOI: 10.1590/1516-4446-2012-1048. View

18.

Kuhner C, Burger C, Keller F, Hautzinger M . [Reliability and validity of the Revised Beck Depression Inventory (BDI-II). Results from German samples]. Nervenarzt. 2006; 78(6):651-6. DOI: 10.1007/s00115-006-2098-7. View

19.

Sommer J, Maboshe W, Griebe M, Heiser C, Hormann K, Stuck B . A mobile olfactometer for fMRI-studies. J Neurosci Methods. 2012; 209(1):189-94. DOI: 10.1016/j.jneumeth.2012.05.026. View

20.

Wilson D, Xu W, Sadrian B, Courtiol E, Cohen Y, Barnes D . Cortical odor processing in health and disease. Prog Brain Res. 2014; 208:275-305. PMC: 4284974. DOI: 10.1016/B978-0-444-63350-7.00011-5. View