Therapeutic Efficacy and Migration of Mesenchymal Stem Cells After Intracerebral Transplantation in Rats with Experimental Ischemic Stroke

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2023 Jun 19

PMID 37336809

Authors

D D Namestnikova

I L Gubskiy

E A Cherkashova

K K Sukhinich

P A Melnikov

A N Gabashvili

V V Kurilo

V P Chekhonin

L V Gubsky

K N Yarygin

Affiliations

Soon will be listed here.

Abstract

We studied therapeutic efficacy and migration characteristics of mesenchymal stem cells isolated from the human placenta after their intracerebral (stereotactic) administration to rats with the experimental ischemic stroke. It was shown that cell therapy significantly improved animal survival rate and reduced the severity of neurological deficit. New data on the migration pathways of transplanted cells in the brain were obtained.

Citing Articles

Estimation of the Ischemic Lesion in the Experimental Stroke Studies Using Magnetic Resonance Imaging (Review).

Namestnikova D, Cherkashova E, Gumin I, Chekhonin V, Yarygin K, Gubskiy I Bull Exp Biol Med. 2024; 176(5):649-657.

PMID: 38733482 DOI: 10.1007/s10517-024-06086-z.

A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke.

Gao Y, Zhang T, Zhang H, Gao J, Yang P Int J Nanomedicine. 2024; 19:327-345.

PMID: 38229707 PMC: 10790665. DOI: 10.2147/IJN.S442304.

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