Cathepsins in Oral Diseases: Mechanisms and Therapeutic Implications

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Jun 19

PMID 37334378

Authors

Hao Jiang

Zuoxiang Dong

Xiaomin Xia

Xue Li

Affiliations

Soon will be listed here.

Abstract

Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis. Findings regarding their functions in human physiological processes and disorders have drawn extensive attention. In this review, we will focus on the relationship between cathepsins and oral diseases. We highlight the structural and functional properties of cathepsins related to oral diseases, as well as the regulatory mechanisms in tissue and cells and their therapeutic uses. Elucidating the associated mechanism between cathepsins and oral diseases is thought to be a promising strategy for the treatment of oral diseases and may be a starting point for further studies at the molecular level.

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