KCO-promoted Synthesis of Amides from 1-aryl-2,2,2-trifluoroethanones and Amines Under Mild Conditions

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 Jun 19

PMID 37333725

Authors

Pinyong Zhong

Yu-Chao Wang

Jin-Biao Liu

Linjun Zhang

Nianhua Luo

Affiliations

Soon will be listed here.

Abstract

A base-promoted amidation of 1-aryl-2,2,2-trifluoroethanones with amines Haller-Bauer reaction has been developed. In this reaction, the direct transformation of 1-aryl-2,2,2-trifluoroethanones into amides C(O)-C bond cleavage occurs without the use of any stoichiometric chemical oxidants or transition-metal catalysts. A series of primary and secondary amines are shown to be compatible with this transformation, and several pharmaceutical molecules were synthesized.

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