Case Report: Levodopa-responsive Parkinsonism with Akinetic Mutism After Ventriculo-peritoneal Shunt

Overview

Journal Front Neurol

Specialty Neurology

Date 2023 Jun 19

PMID 37332998

Authors

Ying Zhang

Ping Li

Jifeng Zhang

Chunyang Li

Peng Sun

Fujun Li

Zhuomin Jiao

Affiliations

Soon will be listed here.

Abstract

Background: Parkinsonism and akinetic mutism (AM) following ventriculo-peritoneal shunt (VPS) without underdrainage used to be considered rare, but may be underdiagnosed in daily clinical practice. Although the pathophysiology is still unclear, in several case reports, the parkinsonism and AM after VPS shows responsiveness to dopaminergic treatment.

Case Presentation: We report a 19-year-old male that presented with severe parkinsonism and AM after VPS. Meanwhile, F-FDG-PET showed a cortical and subcortical hypometabolism. Fortunately, levodopa dramatically improved patient's symptoms and brain hypometabolism. This report provides support for the possibility that dopamine deficiency inhibits brain metabolism, and further elucidates the pathogenesis of parkinsonism and AM.

Conclusion: This report highlights the presentation of a treatable parkinsonism and points out that Levodopa and/or dopamine agonist should be the first choice if the patients develop parkinson-like symptoms after VPS.

Citing Articles

Avoiding Misdiagnosis in Global Rostral Midbrain Syndrome (GRMS): Clinical Insights and Neurorehabilitation Approaches.

Johr J, Alioth A, Catalano Chiuve S, Nazeeruddin S, Belouaer A, Daniel R J Clin Med. 2024; 13(19).

PMID: 39407812 PMC: 11476429. DOI: 10.3390/jcm13195752.

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