Toxicity of Bisphenol in Pregnant Females: First Review of Literature in Humans

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2023 Jun 19

PMID 37332408

Authors

Radhika Agarwal

Shrirang S Joshi

Affiliations

Soon will be listed here.

Abstract

Bisphenol analogues are widely used in consumer products such as disposable dinnerware, canned food, personal care products, bottled beverages, and more, and dietary exposure is the main pathway. Bisphenol A is used to manufacture synthetic resins and commercial plastics in large quantities. According to epidemiological and animal studies, bisphenols disrupt the reproductive, immunological, and metabolic systems. These analogues are estrogenic like Bisphenol A, although human studies are limited. We did a thorough search of the literature on the toxicity of bisphenol on reproductive and endocrine systems in pregnancy, focusing particularly on human studies. Hence, we present a comprehensive literature review on this topic. During our literature search, three epidemiological studies and one human observational study demonstrated a substantial link between bisphenol toxicity and recurrent miscarriages. The aforementioned research shows that bisphenol may harm pregnancy and cause miscarriages. We believe this is the first literature review on the topic.

References

Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N . Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors. Toxicology. 2018; 413:48-55. DOI: 10.1016/j.tox.2018.12.001. View

Liang F, Huo X, Wang W, Li Y, Zhang J, Feng Y . Association of bisphenol A or bisphenol S exposure with oxidative stress and immune disturbance among unexplained recurrent spontaneous abortion women. Chemosphere. 2020; 257:127035. DOI: 10.1016/j.chemosphere.2020.127035. View

Coulam C . Epidemiology of recurrent spontaneous abortion. Am J Reprod Immunol. 1991; 26(1):23-7. DOI: 10.1111/j.1600-0897.1991.tb00697.x. View

Ji K, Hong S, Kho Y, Choi K . Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish. Environ Sci Technol. 2013; 47(15):8793-800. DOI: 10.1021/es400329t. View

Motedayyen H, Rezaei A, Zarnani A, Tajik N . Human amniotic epithelial cells inhibit activation and pro-inflammatory cytokines production of naive CD4+ T cells from women with unexplained recurrent spontaneous abortion. Reprod Biol. 2018; 18(2):182-188. DOI: 10.1016/j.repbio.2018.04.002. View

Gonzalez N, Marques M, Cunha S, Fernandes J, Domingo J, Nadal M . Biomonitoring of co-exposure to bisphenols by consumers of canned foodstuffs. Environ Int. 2020; 140:105760. DOI: 10.1016/j.envint.2020.105760. View

Pan X, Liu X, Li X, Niu N, Yin X, Li N . Association between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis. Int J Fertil Steril. 2015; 8(4):351-66. PMC: 4355921. DOI: 10.22074/ijfs.2015.4174. View

Eladak S, Grisin T, Moison D, Guerquin M, NTumba-Byn T, Pozzi-Gaudin S . A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril. 2014; 103(1):11-21. DOI: 10.1016/j.fertnstert.2014.11.005. View

Meeker J . Exposure to environmental endocrine disruptors and child development. Arch Pediatr Adolesc Med. 2012; 166(6):E1-7. PMC: 3572204. DOI: 10.1001/archpediatrics.2012.241. View

10.

Sugiura-Ogasawara M, Ozaki Y, Sonta S, Makino T, Suzumori K . Exposure to bisphenol A is associated with recurrent miscarriage. Hum Reprod. 2005; 20(8):2325-9. DOI: 10.1093/humrep/deh888. View

11.

Cano-Nicolau J, Vaillant C, Pellegrini E, Charlier T, Kah O, Coumailleau P . Estrogenic Effects of Several BPA Analogs in the Developing Zebrafish Brain. Front Neurosci. 2016; 10:112. PMC: 4805609. DOI: 10.3389/fnins.2016.00112. View

12.

Ullah A, Pirzada M, Jahan S, Ullah H, Shaheen G, Rehman H . Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: Comparative in vitro and in vivo studies on the sperms and testicular tissues of rats. Chemosphere. 2018; 209:508-516. DOI: 10.1016/j.chemosphere.2018.06.089. View

13.

Brieno-Enriquez M, Robles P, Camats-Tarruella N, Garcia-Cruz R, Roig I, Cabero L . Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development. Hum Reprod. 2011; 26(10):2807-18. DOI: 10.1093/humrep/der249. View

14.

Zhu X, Wu G, Xing Y, Wang C, Yuan X, Li B . Evaluation of single and combined toxicity of bisphenol A and its analogues using a highly-sensitive micro-biosensor. J Hazard Mater. 2019; 381:120908. DOI: 10.1016/j.jhazmat.2019.120908. View

15.

Hercog K, Maisanaba S, Filipic M, Sollner-Dolenc M, Kac L, Zegura B . Genotoxic activity of bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF and their mixtures in human hepatocellular carcinoma (HepG2) cells. Sci Total Environ. 2019; 687:267-276. DOI: 10.1016/j.scitotenv.2019.05.486. View

16.

Tsukimori K, Tokunaga S, Shibata S, Uchi H, Nakayama D, Ishimaru T . Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident. Environ Health Perspect. 2008; 116(5):626-30. PMC: 2367658. DOI: 10.1289/ehp.10686. View

17.

Gonzalez N, Cunha S, Ferreira R, Fernandes J, Marques M, Nadal M . Concentrations of nine bisphenol analogues in food purchased from Catalonia (Spain): Comparison of canned and non-canned foodstuffs. Food Chem Toxicol. 2019; 136:110992. DOI: 10.1016/j.fct.2019.110992. View

18.

Zhang B, Wei Y, Niu J, Li Y, Miao Z, Wang Z . Risk factors for unexplained recurrent spontaneous abortion in a population from southern China. Int J Gynaecol Obstet. 2009; 108(2):135-8. DOI: 10.1016/j.ijgo.2009.09.019. View

19.

Ogasawara M, Aoki K, Okada S, Suzumori K . Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril. 2000; 73(2):300-4. DOI: 10.1016/s0015-0282(99)00495-1. View

20.

MacLennan M, Crichton J, Playfoot C, Adams I . Oocyte development, meiosis and aneuploidy. Semin Cell Dev Biol. 2015; 45:68-76. PMC: 4828587. DOI: 10.1016/j.semcdb.2015.10.005. View