Urinary Titin N-fragment As a Predictor of Decreased Skeletal Muscle Mass in Patients with Interstitial Lung Diseases

Overview

Journal Sci Rep

Specialty Science

Date 2023 Jun 15

PMID 37322176

Authors

Masatoshi Hanada

Yuji Ishimatsu

Noriho Sakamoto

Yoshiko Akiyama

Takashi Kido

Hiroshi Ishimoto

Masato Oikawa

Hiroki Nagura

Rina Takeuchi

Shuntaro Sato

Hideaki Takahata

Hiroshi Mukae

Ryo Kozu

Affiliations

Soon will be listed here.

Abstract

This study aimed to examine the validity of urinary N-terminal titin fragment/creatinine (urinary N-titin/Cr) reflecting muscle damage biomarker in patients with interstitial lung disease. This retrospective study enrolled patients with interstitial lung disease. We measured urinary N-titin/Cr. Furthermore, we measured the cross-sectional areas of the pectoralis muscles above the aortic arch (PM) and erector spinae muscles of the 12th thoracic vertebra muscles (ESM) to assess muscle mass until 1 year. We examined the correlation between urinary N-titin/Cr and the change in muscle mass. We plotted receiver operating characteristic curves to estimate the cut-off points for urinary N-titin/Cr for distinguishing the greater-than-median and smaller-than-median reduction of muscle mass after 1 year. We enrolled 68 patients with interstitial lung disease. The median urinary N-titin/Cr value was 7.0 pmol/mg/dL. We observed significant negative correlations between urinary N-titin/Cr and changes in the PM after 1 year (p < 0.001) and changes in the ESM after 6 months (p < 0.001) and 1 year (p < 0.001). The cut-off points for urinary N-titin/Cr were 5.2 pmol/mg/dL and 10.4 pmol/mg/dL in the PM and ESM, respectively. In summary, urinary N-titin/Cr may predict muscle loss in the long-term and act as a clinically useful biomarker reflecting muscle damage.

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