The Serotonin Theory of Depression

Overview

Journal Mol Psychiatry

Specialties Molecular Biology
Psychiatry

Date 2023 Jun 15

PMID 37322061

Authors

Rif S El-Mallakh

Masoud Doroodgar

Omar H Elsayed

Neil Kidambi

Affiliations

Soon will be listed here.

Citing Articles

Dynamics of human serotonin synthesis differentially link to reward anticipation and feedback.

Hahn A, Reed M, Murgas M, Vraka C, Klug S, Schmidt C Mol Psychiatry. 2024; 30(2):600-607.

PMID: 39179904 PMC: 11746133. DOI: 10.1038/s41380-024-02696-1.

Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder.

Page C, Epperson C, Novick A, Duffy K, Thompson S Mol Psychiatry. 2024; 29(12):3802-3813.

PMID: 38816586 PMC: 11692567. DOI: 10.1038/s41380-024-02625-2.

Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability.

Du W, Chen H, Grof I, Lemaitre L, Bocsik A, Perdyan A Mol Psychiatry. 2024; 29(11):3590-3598.

PMID: 38816584 PMC: 11541205. DOI: 10.1038/s41380-024-02626-1.

References

Cipriani A, Furukawa T, Salanti G, Chaimani A, Atkinson L, Ogawa Y . Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018; 391(10128):1357-1366. PMC: 5889788. DOI: 10.1016/S0140-6736(17)32802-7. View

Meyniel F, Goodwin G, Deakin J, Klinge C, MacFadyen C, Milligan H . A specific role for serotonin in overcoming effort cost. Elife. 2016; 5. PMC: 5100997. DOI: 10.7554/eLife.17282. View

El-Mallakh R, Gao Y, Roberts R . Tardive dysphoria: the role of long term antidepressant use in-inducing chronic depression. Med Hypotheses. 2011; 76(6):769-73. DOI: 10.1016/j.mehy.2011.01.020. View

Fava G . May antidepressant drugs worsen the conditions they are supposed to treat? The clinical foundations of the oppositional model of tolerance. Ther Adv Psychopharmacol. 2020; 10:2045125320970325. PMC: 7649913. DOI: 10.1177/2045125320970325. View