Antiviral Strategies for Epidemic and Pandemic Preparedness
Overview
Microbiology
Authors
Affiliations
Broad(er)-acting antiviral drugs, active against entire genera or families of viruses, should be developed and stockpiled in epidemic/pandemic peacetime. They can be used to counter outbreaks as soon as the new virus has been identified and will also remain important pharmacological tools after the introduction of vaccines and monoclonal antibodies.
Hyperforin, the major metabolite of St. John's wort, exhibits pan-coronavirus antiviral activity.
Raczkiewicz I, Riviere C, Bouquet P, Desmarets L, Tarricone A, Camuzet C Front Microbiol. 2024; 15:1443183.
PMID: 39176276 PMC: 11339956. DOI: 10.3389/fmicb.2024.1443183.
Sibille G, Mannino G, Frasson I, Pavan M, Luganini A, Salata C Int J Mol Sci. 2024; 25(13).
PMID: 39000477 PMC: 11242173. DOI: 10.3390/ijms25137370.
Multiplexed multicolor antiviral assay amenable for high-throughput research.
Li L, Chiu W, Huang Y, Rasulova M, Vercruysse T, Thibaut H Nat Commun. 2024; 15(1):42.
PMID: 38168091 PMC: 10761739. DOI: 10.1038/s41467-023-44339-z.