Epizootic Hemorrhagic Disease Virus: Current Knowledge and Emerging Perspectives

Overview

Journal Microorganisms

Specialty Microbiology

Date 2023 Jun 15

PMID 37317313

Authors

Luis Jimenez-Cabello

Sergio Utrilla-Trigo

Gema Lorenzo

Javier Ortego

Eva Calvo-Pinilla

Affiliations

Soon will be listed here.

Abstract

Epizootic Hemorrhagic Disease (EHD) of ruminants is a viral pathology that has significant welfare, social, and economic implications. The causative agent, epizootic hemorrhagic disease virus (EHDV), belongs to the genus and leads to significant regional disease outbreaks among livestock and wildlife in North America, Asia, Africa, and Oceania, causing significant morbidity and mortality. During the past decade, this viral disease has become a real threat for countries of the Mediterranean basin, with the recent occurrence of several important outbreaks in livestock. Moreover, the European Union registered the first cases of EHDV ever detected within its territory. Competent vectors involved in viral transmission, midges, are expanding its distribution, conceivably due to global climate change. Therefore, livestock and wild ruminants around the globe are at risk for this serious disease. This review provides an overview of current knowledge about EHDV, including changes of distribution and virulence, an examination of different animal models of disease, and a discussion about potential treatments to control the disease.

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