Conformationally Flexible Cleft Receptor for Chloride Anion Transport

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Jun 12

PMID 37305253

Authors

Raju Biswas

Krishanu Samanta

Sandipan Ghorai

Suman Maji

Ramalingam Natarajan

Affiliations

Soon will be listed here.

Abstract

The design and synthesis of a cleft-shaped bis-diarylurea receptor for chloride anion transport is reported in this work. The receptor is based on the foldameric nature of ,-diphenylurea upon its dimethylation. The bis-diarylurea receptor exhibits a strong and selective affinity for chloride over bromide and iodide anions. A nanomolar quantity of the receptor efficiently transports the chloride across a lipid bilayer membrane as a 1:1 complex (EC = 5.23 nm). The work demonstrates the utility of the ,-dimethyl-,-diphenylurea scaffold in anion recognition and transport.

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