The Tumor Suppressor Role and CeRNA Network of MiR-1294 in Cancer

Overview

Journal Oncol Res

Specialty Oncology

Date 2023 Jun 12

PMID 37303740

Authors

Yunan Mao

Jinze Shen

L I Fang

Feng Zhu

Shiwei Duan

Affiliations

Soon will be listed here.

Abstract

miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical significance of the tumor suppressor miR-1294 in cancer.

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