Oral and Craniofacial Research in the Generation R Study: an Executive Summary

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2023 Jun 10

PMID 37301790

Authors

Agatha W van Meijeren-van Lunteren

Xianjing Liu

Francien C H Veenman

Olja Grgic

Brunilda Dhamo

Justin T van der Tas

Vid Prijatelj

Gennady V Roshchupkin

Fernando Rivadeneira

Eppo B Wolvius

Lea Kragt

Affiliations

Soon will be listed here.

Abstract

Objectives: Oral conditions are of high prevalence and chronic character within the general population. Identifying the risk factors and determinants of oral disease is important, not only to reduce the burden of oral diseases, but also to improve (equal access to) oral health care systems, and to develop effective oral health promotion programs. Longitudinal population-based (birth-)cohort studies are very suitable to study risk factors on common oral diseases and have the potential to emphasize the importance of a healthy start for oral health. In this paper, we provide an overview of the comprehensive oral and craniofacial dataset that has been collected in the Generation R study: a population-based prospective birth cohort in the Netherlands that was designed to identify causes of health from fetal life until adulthood.

Methods: Within the multidisciplinary context of the Generation R study, oral and craniofacial data has been collected from the age of 3 years onwards, and continued at the age of six, nine, and thirteen. Data collection is continuing in 17-year-old participants.

Research Outcomes: In total, the cohort population comprised 9749 children at birth, and 7405 eligible participants at the age of seventeen. Based on questionnaires, the dataset contains information on oral hygiene, dental visits, oral habits, oral health-related quality of life, orthodontic treatment, and obstructive sleep apnea. Based on direct measurements, the dataset contains information on dental caries, developmental defects of enamel, objective orthodontic treatment need, dental development, craniofacial characteristics, mandibular cortical thickness, and 3D facial measurements.

Conclusions: Several research lines have been set up using the oral and craniofacial data linked with the extensive data collection that exists within the Generation R study.

Clinical Relevance: Being embedded in a multidisciplinary and longitudinal birth cohort study allows researchers to study several determinants of oral and craniofacial health, and to provide answers and insight into unknown etiologies and oral health problems in the general population.

Citing Articles

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Poverty Dynamics and Caries Status in Young Adolescents.

Carbajal Rodriguez G, van Meijeren-van Lunteren A, Wolvius E, Kragt L Community Dent Oral Epidemiol. 2024; 53(1):90-97.

PMID: 39390670 PMC: 11754150. DOI: 10.1111/cdoe.13012.

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