Relationship Between Gut Microbiota and Allergies in Children: A Literature Review

Overview

Journal Nutrients

Date 2023 Jun 10

PMID 37299492

Authors

Alexandru Cosmin Pantazi

Cristina Maria Mihai

Adriana Luminita Balasa

Tatiana Chisnoiu

Ancuta Lupu

Corina Elena Frecus

Larisia Mihai

Adina Ungureanu

Mustafa Ali Kassim Kassim

Antonio Andrusca

Maria Nicolae

Viviana Cuzic

Vasile Valeriu Lupu

Simona Claudia Cambrea

Affiliations

Soon will be listed here.

Abstract

The intestinal microbiota is a diverse and complex microecosystem that lives and thrives within the human body. The microbiota stabilizes by the age of three. This microecosystem plays a crucial role in human health, particularly in the early years of life. Dysbiosis has been linked to the development of various allergic diseases with potential long-term implications. Next-generation sequencing methods have established that allergic diseases are associated with dysbiosis. These methods can help to improve the knowledge of the relationship between dysbiosis and allergic diseases. The aim of this review paper is to synthesize the current understanding on the development of the intestinal microbiota in children, the long-term impact on health, and the relationship between dysbiosis and allergic diseases. Furthermore, we examine the connection between the microbiome and specific allergies such as atopic dermatitis, asthma, and food allergies, and which mechanisms could determine the induction of these diseases. Furthermore, we will review how factors such as mode of delivery, antibiotic use, breastfeeding, and the environment influence the development of the intestinal flora, as well as review various interventions for the prevention and treatment of gut microbiota-related allergies.

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