Cardioprotective Properties of Kaempferol: A Review

Overview

Journal Plants (Basel)

Date 2023 Jun 10

PMID 37299076

Authors

Yusof Kamisah

Juriyati Jalil

Nurhanan Murni Yunos

Satirah Zainalabidin

Affiliations

Soon will be listed here.

Abstract

Cardiac diseases, such as myocardial infarction and heart failure, have become a major clinical problem globally. The accumulating data demonstrate that bioactive compounds with antioxidant and anti-inflammatory properties have favorable effects on clinical problems. Kaempferol is a flavonoid found in various plants; it has demonstrated cardioprotective properties in numerous cardiac injury models. This review aims to collate updated information regarding the effects of kaempferol on cardiac injury. Kaempferol improves cardiac function by alleviating myocardial apoptosis, fibrosis, oxidative stress, and inflammation while preserving mitochondrial function and calcium homeostasis. However, the mechanisms of action of its cardioprotective properties remain unclear; therefore, elucidating its action could provide insight into directions for future studies.

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