The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jun 10

PMID 37298268

Authors

Yongqiang Wen

Yazhou Wang

Chenxu Zhao

Baoyu Zhao

Jianguo Wang

Affiliations

Soon will be listed here.

Abstract

Baicalin is one of the most abundant flavonoids found in the dried roots of Georgi (SBG) belonging to the genus . While baicalin is demonstrated to have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity and lipophilicity limit the bioavailability and pharmacological functions. Therefore, an in-depth study of baicalin's bioavailability and pharmacokinetics contributes to laying the theoretical foundation for applied research in disease treatment. In this view, the physicochemical properties and anti-inflammatory activity of baicalin are summarized in terms of bioavailability, drug interaction, and inflammatory conditions.

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