Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jun 10

PMID 37298174

Authors

Flavia Tasmin Techera Antunes

Maria Martha Campos

Vanice de Paula Ricardo Carvalho

Claudio Antonio da Silva Junior

Luiz Alexandre Viana Magno

Alessandra Hubner de Souza

Marcus Vinicius Gomez

Affiliations

Soon will be listed here.

Abstract

Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.

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