Lunasin and Its Epigenetic Impact in Cancer Chemoprevention

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jun 10

PMID 37298139

Authors

Agnieszka Kaufman-Szymczyk

Wiktoria Kaczmarek

Krystyna Fabianowska-Majewska

Katarzyna Lubecka-Gajewska

Affiliations

Soon will be listed here.

Abstract

Cancer diseases are a leading cause of death worldwide. Therefore, it is pivotal to search for bioactive dietary compounds that can avert tumor development. A diet rich in vegetables, including legumes, provides chemopreventive substances, which have the potential to prevent many diseases, including cancer. Lunasin is a soy-derived peptide whose anti-cancer activity has been studied for over 20 years. The results of the previous research have shown that lunasin inhibits histone acetylation, regulates the cell cycle, suppresses proliferation and induces apoptosis of cancer cells. Thus, lunasin seems to be a promising bioactive anti-cancer agent and a potent epigenetic modulator. The present review discusses studies of the underlying molecular mechanisms and new perspectives on lunasin application in epigenetic prevention and anti-cancer therapy.

Citing Articles

Cytotoxic Effects of Plant Secondary Metabolites and Naturally Occurring Bioactive Peptides on Breast Cancer Model Systems: Molecular Mechanisms.

Zasheva D, Mladenov P, Zapryanova S, Gospodinova Z, Georgieva M, Alexandar I Molecules. 2024; 29(22).

PMID: 39598664 PMC: 11596968. DOI: 10.3390/molecules29225275.

Encapsulation of soybean lunasin and amaranth unsaponifiable matter in liposomes induces cell cycle arrest in an allograft melanoma mouse model.

Castaneda-Reyes E, Gonzalez-Almazan A, Lubbert-Licon A, Yahya N, Gonzalez de Mejia E Sci Rep. 2024; 14(1):27858.

PMID: 39537778 PMC: 11561292. DOI: 10.1038/s41598-024-79448-2.

References

Hernandez-Ledesma B, Hsieh C, de Lumen B . Lunasin, a novel seed peptide for cancer prevention. Peptides. 2008; 30(2):426-30. DOI: 10.1016/j.peptides.2008.11.002. View

Wang W, Bringe N, Berhow M, Gonzalez de Mejia E . beta-Conglycinins among sources of bioactives in hydrolysates of different soybean varieties that inhibit leukemia cells in vitro. J Agric Food Chem. 2008; 56(11):4012-20. DOI: 10.1021/jf8002009. View

Tompa P . The interplay between structure and function in intrinsically unstructured proteins. FEBS Lett. 2005; 579(15):3346-54. DOI: 10.1016/j.febslet.2005.03.072. View

Hsieh C, Chou M, Wang C . Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production. PLoS One. 2017; 12(2):e0171969. PMC: 5300240. DOI: 10.1371/journal.pone.0171969. View

Galvez A, Huang L, Magbanua M, Dawson K, Rodriguez R . Differential expression of thrombospondin (THBS1) in tumorigenic and nontumorigenic prostate epithelial cells in response to a chromatin-binding soy peptide. Nutr Cancer. 2011; 63(4):623-36. PMC: 3210036. DOI: 10.1080/01635581.2011.539312. View

Hsieh C, Wu C, Peng S, Chang C . Seed-derived peptide lunasin suppressed breast cancer cell growth by regulating inflammatory mediators, aromatase, and estrogen receptors. Food Nutr Res. 2023; 67. PMC: 9899045. DOI: 10.29219/fnr.v67.8991. View

Lubecka-Pietruszewska K, Kaufman-Szymczyk A, Stefanska B, Cebula-Obrzut B, Smolewski P, Fabianowska-Majewska K . Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells. J Nutrigenet Nutrigenomics. 2015; 8(2):91-101. DOI: 10.1159/000439111. View

Lule V, Garg S, Pophaly S, Hitesh , Tomar S . "Potential health benefits of lunasin: a multifaceted soy-derived bioactive peptide". J Food Sci. 2015; 80(3):R485-94. DOI: 10.1111/1750-3841.12786. View

Kaufman-Szymczyk A, Majewski G, Lubecka-Pietruszewska K, Fabianowska-Majewska K . The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation. Int J Mol Sci. 2015; 16(12):29732-43. PMC: 4691138. DOI: 10.3390/ijms161226195. View

10.

DAlessio A, Szyf M . Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation. Biochem Cell Biol. 2006; 84(4):463-76. DOI: 10.1139/o06-090. View

11.

Dia V, Gonzalez de Mejia E . Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling. Cancer Lett. 2011; 313(2):167-80. DOI: 10.1016/j.canlet.2011.09.002. View

12.

Dia V, Gonzalez de Mejia E . Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression. Cancer Lett. 2010; 295(1):44-53. DOI: 10.1016/j.canlet.2010.02.010. View

13.

Bigey P, Ramchandani S, Theberge J, Araujo F, Szyf M . Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene. 2000; 242(1-2):407-18. DOI: 10.1016/s0378-1119(99)00501-6. View

14.

Lubecka K, Kaufman-Szymczyk A, Cebula-Obrzut B, Smolewski P, Szemraj J, Fabianowska-Majewska K . Novel Clofarabine-Based Combinations with Polyphenols Epigenetically Reactivate Retinoic Acid Receptor Beta, Inhibit Cell Growth, and Induce Apoptosis of Breast Cancer Cells. Int J Mol Sci. 2018; 19(12). PMC: 6321577. DOI: 10.3390/ijms19123970. View

15.

Blumenfeld A, Fleshner N, CASSELMAN B, Trachtenberg J . Nutritional aspects of prostate cancer: a review. Can J Urol. 2000; 7(1):927-35; discussion 936. View

16.

Lubecka K, Kurzava L, Flower K, Buvala H, Zhang H, Teegarden D . Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity. Carcinogenesis. 2016; 37(7):656-68. PMC: 4936385. DOI: 10.1093/carcin/bgw048. View

17.

Jeong H, Park J, Lam Y, de Lumen B . Characterization of lunasin isolated from soybean. J Agric Food Chem. 2003; 51(27):7901-6. DOI: 10.1021/jf034460y. View

18.

Hashimoto H, Vertino P, Cheng X . Molecular coupling of DNA methylation and histone methylation. Epigenomics. 2011; 2(5):657-69. PMC: 3039846. DOI: 10.2217/epi.10.44. View

19.

Cruz-Huerta E, Fernandez-Tome S, Arques M, Amigo L, Recio I, Clemente A . The protective role of the Bowman-Birk protease inhibitor in soybean lunasin digestion: the effect of released peptides on colon cancer growth. Food Funct. 2015; 6(8):2626-35. DOI: 10.1039/c5fo00454c. View

20.

Hernandez-Ledesma B, Hsieh C, de Lumen B . Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation. Mol Nutr Food Res. 2011; 55(7):989-98. DOI: 10.1002/mnfr.201000632. View