Alpha 2.0

» Articles » PMID: 37297860

Advances in Cardiovascular Pharmacology in Atherosclerotic-Related Therapeutic Areas: Addressing Patients' Clinical Needs

Overview

Overview

Journal J Clin Med

Specialty General Medicine

Date 2023 Jun 10

PMID 37297860

Authors

Authors

Muntaser Omari

Mohammad Alkhalil

Affiliations

Affiliations

Soon will be listed here.

Abstract

Over the last three decades, a significant improvement has been achieved in reducing cardiovascular morbidity and mortality [...].

References

1.

Alkhalil M, Kearney A, Hegarty M, Stewart C, Devlin P, Owens C . Eosinopenia as an Adverse Marker of Clinical Outcomes in Patients Presenting with Acute Myocardial Infarction. Am J Med. 2019; 132(12):e827-e834. DOI: 10.1016/j.amjmed.2019.05.021. View

2.

Miller G, MILLER N . Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975; 1(7897):16-9. DOI: 10.1016/s0140-6736(75)92376-4. View

3.

Bhatt D, Stone G, Mahaffey K, Gibson C, Steg P, Hamm C . Effect of platelet inhibition with cangrelor during PCI on ischemic events. N Engl J Med. 2013; 368(14):1303-13. DOI: 10.1056/NEJMoa1300815. View

4.

Mehta S, Yusuf S, Peters R, Bertrand M, Lewis B, Natarajan M . Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001; 358(9281):527-33. DOI: 10.1016/s0140-6736(01)05701-4. View

5.

Alkhalil M, Edmond E, Edgar L, Digby J, Omar O, Robson M . The relationship of perivascular adipose tissue and atherosclerosis in the aorta and carotid arteries, determined by magnetic resonance imaging. Diab Vasc Dis Res. 2018; 15(4):286-293. PMC: 6039860. DOI: 10.1177/1479164118757923. View

6.

Landray M, Haynes R, Hopewell J, Parish S, Aung T, Tomson J . Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med. 2014; 371(3):203-12. DOI: 10.1056/NEJMoa1300955. View

7.

Varbo A, Benn M, Tybjaerg-Hansen A, Nordestgaard B . Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. Circulation. 2013; 128(12):1298-309. DOI: 10.1161/CIRCULATIONAHA.113.003008. View

8.

Tricoci P, Lokhnygina Y, Huang Z, Van de Werf F, Cornel J, Chen E . Vorapaxar with or without clopidogrel after non-ST-segment elevation acute coronary syndromes: results from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome trial. Am Heart J. 2014; 168(6):869-77.e1. DOI: 10.1016/j.ahj.2014.09.002. View

9.

Weitz J, Eikelboom J . What Is the Future of Factor XI Inhibitors?. Circulation. 2022; 146(25):1899-1902. DOI: 10.1161/CIRCULATIONAHA.122.061132. View

10.

Sarwar N, Sandhu M, Ricketts S, Butterworth A, Di Angelantonio E, Boekholdt S . Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet. 2010; 375(9726):1634-9. PMC: 2867029. DOI: 10.1016/S0140-6736(10)60545-4. View

11.

Visseren F, Mach F, Smulders Y, Carballo D, Koskinas K, Back M . 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021; 42(34):3227-3337. DOI: 10.1093/eurheartj/ehab484. View

12.

Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray K, Thompson A . Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009; 302(18):1993-2000. PMC: 3284229. DOI: 10.1001/jama.2009.1619. View

13.

Alkhalil M . Effects of intensive lipid-lowering therapy on mortality after coronary bypass surgery: A meta-analysis of 7 randomised trials. Atherosclerosis. 2019; 293:75-78. DOI: 10.1016/j.atherosclerosis.2019.12.006. View

14.

Nissen S, Lincoff A, Brennan D, Ray K, Mason D, Kastelein J . Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023; 388(15):1353-1364. DOI: 10.1056/NEJMoa2215024. View

15.

Sinnaeve P, Fahrni G, Schelfaut D, Spirito A, Mueller C, Frenoux J . Subcutaneous Selatogrel Inhibits Platelet Aggregation in Patients With Acute Myocardial Infarction. J Am Coll Cardiol. 2020; 75(20):2588-2597. DOI: 10.1016/j.jacc.2020.03.059. View

16.

Nordestgaard B, Benn M, Schnohr P, Tybjaerg-Hansen A . Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007; 298(3):299-308. DOI: 10.1001/jama.298.3.299. View

17.

Ridker P, Cushman M, Stampfer M, Tracy R, Hennekens C . Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997; 336(14):973-9. DOI: 10.1056/NEJM199704033361401. View

18.

von Eckardstein A, Nordestgaard B, Remaley A, Catapano A . High-density lipoprotein revisited: biological functions and clinical relevance. Eur Heart J. 2022; 44(16):1394-1407. PMC: 10119031. DOI: 10.1093/eurheartj/ehac605. View

19.

Wallentin L, Becker R, Budaj A, Cannon C, Emanuelsson H, Held C . Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009; 361(11):1045-57. DOI: 10.1056/NEJMoa0904327. View

20.

Lincoff A, Nicholls S, Riesmeyer J, Barter P, Brewer H, Fox K . Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. N Engl J Med. 2017; 376(20):1933-1942. DOI: 10.1056/NEJMoa1609581. View