Have We Overlooked the Role of Mifepristone for the Medical Management of Tubal Ectopic Pregnancy?

Overview

Journal Hum Reprod

Publisher Oxford University Press

Specialty Reproductive Medicine

Date 2023 Jun 9

PMID 37295950

Authors

Julia Oltman

Sanjana Balachander

Ben W Mol

Andrea M F Woolner

Affiliations

Soon will be listed here.

Abstract

Ectopic pregnancy is a risk of both spontaneous and assisted reproduction pregnancies. The majority of ectopic pregnancies abnormally implant within a fallopian tube (extrauterine pregnancies). In haemodynamically stable women, medical or expectant treatment can be offered. Currently accepted medical treatment is using a drug called methotrexate. However, methotrexate has potential adverse effects, and a significant proportion of women will still require emergency surgery (up to 30%) to remove the ectopic pregnancy. Mifepristone (RU-486) has anti-progesterone effects and has a role in managing intrauterine pregnancy loss and termination of pregnancy. On reviewing the literature and given progesterone's pivotal role in sustaining pregnancy, we propose that we may have overlooked the role of mifepristone in the medical management of tubal ectopic pregnancy in haemodynamically stable women.

Citing Articles

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Chong K, de Waard L, Oza M, van Wely M, Jurkovic D, Memtsa M Nat Rev Dis Primers. 2024; 10(1):94.

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Targeting human progesterone receptor (PR), through pharmacophore-based screening and molecular simulation revealed potent inhibitors against breast cancer.

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