Selective Cleavage of Lignin Model Compounds Via a Reverse Biosynthesis Mechanism

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2023 Jun 9

PMID 37294132

Authors

Sang Mi Suh

Subramanian Jambu

Mason T Chin

Tianning Diao

Affiliations

Soon will be listed here.

Abstract

Selective depolymerization of lignin remains a significant challenge in biomass conversion. The biosynthesis of lignin involves the polymerization of monolignol building blocks through oxidative radical coupling reactions. A strategy for lignin degradation leverages photoredox deoxygenative radical formation to trigger reverse biosynthesis, which cleaves model compounds of the β-O-4 and β-5-β-O-4 linkages to produce monolignols, precursors to flavoring compounds. This mild method preserves important oxygen functionality and serves as a platform for achieving selective lignin depolymerization.

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