Human T-cell Leukemia Virus Type 1 is Associated with Dysthyroidism in the French Amazon

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2023 Jun 9

PMID 37293205

Authors

Julia Dugardin

Magalie Demar

Nezha Hafsi

Hakim Amroun

Jean-Markens Aurelus

Kinan Drak Alsibai

Andre Ntoutoum

Florin Santa

Mathieu Nacher

Nadia Sabbah

Affiliations

Soon will be listed here.

Abstract

Background: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus known to cause two major diseases: adult T-cell leukemia/lymphoma and a progressive neuromyelopathy-tropical spastic paraparesis. Many viruses may be involved in the pathogenesis of thyroiditis; however, few studies have focused on the role of HTLV-1. We aimed to investigate the association between HTLV-1 and biological thyroid dysfunction.

Methods: We included 357 patients with a positive HTLV-1 serology and thyroid-stimulating hormone assay data between 2012 and 2021 in a hospital in French Guiana; we compared the prevalence of hypothyroidism and hyperthyroidism in this group with that in an HTLV-1-negative control group (722 persons) matched for sex and age.

Results: The prevalence of hypothyroidism and hyperthyroidism in patients with HTLV-1 infection was significantly higher than that in the control group (11% versus 3.2% and 11.3% versus 2.3%, respectively; < 0.001).

Conclusion: Our study shows, for the first time, the association between HTLV-1 and dysthyroidism in a large sample, suggesting that thyroid function exploration should be systematically implemented in this population as this may have an impact on therapeutic management.

Citing Articles

Human T-cell lymphotropic virus screening in France: Missed opportunities? A retrospective multicenter study of serological testing in hospital laboratories.

Moquet O, Faye I, Auffret N, Garin B, Brichler S, Cesaire R IJID Reg. 2024; 12:100387.

PMID: 39041060 PMC: 11262194. DOI: 10.1016/j.ijregi.2024.100387.

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