Ubiquitin Ligase Enzymes and De-ubiquitinating Enzymes Regulate Innate Immunity in the TLR, NLR, RLR, and CGAS-STING Pathways

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2023 Jun 8

PMID 37291329

Authors

Wang Jiang

Mengling Li

Siyuan Peng

Tian Hu

Yan Long

Jiayi Zhang

Dan Peng

Yueming Shen

Affiliations

Soon will be listed here.

Abstract

Ubiquitination (or ubiquitylation) and de-ubiquitination, which are both post-translational modifications (PTMs) of proteins, have become a research hotspot in recent years. Some ubiquitinated or de-ubiquitinated signaling proteins have been found to promote or suppress innate immunity through Toll-like receptor (TLR), RIG-like receptor (RIG-I-like receptor, RLR), NOD-like receptor (NLR), and the cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS)-STING pathway. This article aimed to provide a review on the role of ubiquitination and de-ubiquitination, especially ubiquitin ligase enzymes and de-ubiquitinating enzymes, in the above four pathways. We hope that our work can contribute to the research and development of treatment strategies for innate immunity-related diseases such as inflammatory bowel disease.

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