Humoral Immunity Against Aspergillus Fumigatus

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 2023 Jun 8

PMID 37289362

Authors

Sarah Delliere

Vishukumar Aimanianda

Affiliations

Soon will be listed here.

Abstract

Aspergillus fumigatus is one the most ubiquitous airborne opportunistic human fungal pathogens. Understanding its interaction with host immune system, composed of cellular and humoral arm, is essential to explain the pathobiology of aspergillosis disease spectrum. While cellular immunity has been well studied, humoral immunity has been poorly acknowledge, although it plays a crucial role in bridging the fungus and immune cells. In this review, we have summarized available data on major players of humoral immunity against A. fumigatus and discussed how they may help to identify at-risk individuals, be used as diagnostic tools or promote alternative therapeutic strategies. Remaining challenges are highlighted and leads are given to guide future research to better grasp the complexity of humoral immune interaction with A. fumigatus.

Citing Articles

IL-17 in plasma and bronchoalveolar lavage fluid in non-neutropenic patients with invasive pulmonary aspergillosis.

He Q, Cao J, Zhang M, Feng C Front Cell Infect Microbiol. 2024; 14:1402888.

PMID: 39176263 PMC: 11339031. DOI: 10.3389/fcimb.2024.1402888.

Proteome and Dihydrorhodamine Profiling of Bronchoalveolar Lavage in Patients with Chronic Pulmonary Aspergillosis.

Assing K, Laursen C, Campbell A, Beck H, Davidsen J J Fungi (Basel). 2024; 10(5).

PMID: 38786669 PMC: 11122433. DOI: 10.3390/jof10050314.

Diagnosis of Chronic Pulmonary Aspergillosis: Clinical, Radiological or Laboratory?.

Barac A, Vujovic A, Drazic A, Stevanovic G, Paglietti B, Lukic K J Fungi (Basel). 2023; 9(11).

PMID: 37998889 PMC: 10672318. DOI: 10.3390/jof9111084.

References

Donnelly J, Chen S, Kauffman C, Steinbach W, Baddley J, Verweij P . Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2019; 71(6):1367-1376. PMC: 7486838. DOI: 10.1093/cid/ciz1008. View

Alanio A, Delliere S, Fodil S, Bretagne S, Megarbane B . Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19. Lancet Respir Med. 2020; 8(6):e48-e49. PMC: 7239617. DOI: 10.1016/S2213-2600(20)30237-X. View

Denning D, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S . Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2015; 47(1):45-68. DOI: 10.1183/13993003.00583-2015. View

Camara B, Reymond E, Saint-Raymond C, Roth H, Brenier-Pinchart M, Pinel C . Characteristics and outcomes of chronic pulmonary aspergillosis: a retrospective analysis of a tertiary hospital registry. Clin Respir J. 2014; 9(1):65-73. DOI: 10.1111/crj.12105. View

Park S, Mehrad B . Innate immunity to Aspergillus species. Clin Microbiol Rev. 2009; 22(4):535-51. PMC: 2772361. DOI: 10.1128/CMR.00014-09. View

Brown G . Innate antifungal immunity: the key role of phagocytes. Annu Rev Immunol. 2010; 29:1-21. PMC: 3434799. DOI: 10.1146/annurev-immunol-030409-101229. View

Latge J . Tasting the fungal cell wall. Cell Microbiol. 2010; 12(7):863-72. DOI: 10.1111/j.1462-5822.2010.01474.x. View

Gastebois A, Clavaud C, Aimanianda V, Latge J . Aspergillus fumigatus: cell wall polysaccharides, their biosynthesis and organization. Future Microbiol. 2009; 4(5):583-95. DOI: 10.2217/fmb.09.29. View

Speth C, Rambach G, Wurzner R, Lass-Florl C . Complement and fungal pathogens: an update. Mycoses. 2008; 51(6):477-96. DOI: 10.1111/j.1439-0507.2008.01597.x. View

10.

Braem S, Rooijakkers S, van Kessel K, de Cock H, Wosten H, van Strijp J . Effective Neutrophil Phagocytosis of Aspergillus fumigatus Is Mediated by Classical Pathway Complement Activation. J Innate Immun. 2015; 7(4):364-74. PMC: 6738756. DOI: 10.1159/000369493. View

11.

Henwick S, Hetherington S, Patrick C . Complement binding to Aspergillus conidia correlates with pathogenicity. J Lab Clin Med. 1993; 122(1):27-35. View

12.

van de Bovenkamp F, Dijkstra D, van Kooten C, Gelderman K, Trouw L . Circulating C1q levels in health and disease, more than just a biomarker. Mol Immunol. 2021; 140:206-216. DOI: 10.1016/j.molimm.2021.10.010. View

13.

Kozel T, Wilson M, Farrell T, Levitz S . Activation of C3 and binding to Aspergillus fumigatus conidia and hyphae. Infect Immun. 1989; 57(11):3412-7. PMC: 259839. DOI: 10.1128/iai.57.11.3412-3417.1989. View

14.

Sturtevant J, Latge J . Interactions between conidia of Aspergillus fumigatus and human complement component C3. Infect Immun. 1992; 60(5):1913-8. PMC: 257094. DOI: 10.1128/iai.60.5.1913-1918.1992. View

15.

Shende R, Wong S, Rapole S, Beau R, Ibrahim-Granet O, Monod M . conidial metalloprotease Mep1p cleaves host complement proteins. J Biol Chem. 2018; 293(40):15538-15555. PMC: 6177592. DOI: 10.1074/jbc.RA117.001476. View

16.

Waldorf A, DIAMOND R . Neutrophil chemotactic responses induced by fresh and swollen Rhizopus oryzae spores and Aspergillus fumigatus conidia. Infect Immun. 1985; 48(2):458-63. PMC: 261344. DOI: 10.1128/iai.48.2.458-463.1985. View

17.

Wallis R . Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway. Immunobiology. 2007; 212(4-5):289-99. PMC: 2592599. DOI: 10.1016/j.imbio.2006.11.004. View

18.

Rosbjerg A, Wurzner R, Garred P, Skjoedt M . MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis. J Innate Immun. 2021; 13(4):211-224. PMC: 8460983. DOI: 10.1159/000514546. View

19.

Ma Y, Doni A, Hummelshoj T, Honore C, Bastone A, Mantovani A . Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem. 2009; 284(41):28263-28275. PMC: 2788878. DOI: 10.1074/jbc.M109.009225. View

20.

Foo S, Reading P, Jaillon S, Mantovani A, Mahalingam S . Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?. Trends Microbiol. 2015; 23(12):799-811. PMC: 7127210. DOI: 10.1016/j.tim.2015.09.006. View