Non-odontogenic Maxillofacial Infections - a 17-years Retrospective Cohort Study

Overview

Journal Oral Maxillofac Surg

Specialties Dentistry
General Surgery

Date 2023 Jun 8

PMID 37289303

Authors

Ruta Rasteniene

Gabriele Simenaite

Linas Zaleckas

Jolanta Aleksejuniene

Affiliations

Soon will be listed here.

Abstract

Purpose: A retrospective 17-year review of the epidemiology, microbiological aspects, and treatment of patients hospitalized for non-odontogenic maxillofacial infections.

Methods: A retrospective study reviewed 4040 medical records of patients hospitalized at Vilnius University Hospital Zalgiris Clinic during the period of 2003 to 2019. The following data were collected: patient sociodemographic characteristics, length of hospitalization, sources of infection, affected anatomical regions, treatment modalities, microbiological findings, and sensitivity to antibiotics.

Results: The mean (sd) annual incidence of non-odontogenic maxillofacial infections over the past 17 years was 237 (49) cases, and the mean (sd) hospital stay was 7.3 (4.5) days. The male-to-female ratio was 1.9:1, while the mean (sd) patient age was 42.1 (19.0) years. The need for an additional incision and the involvement of multiple anatomical regions were the strongest predictors of longer hospitalization. A total of 139 microorganism species were identified, with Bacteroides, Prevotella, and Staphylococcus showing the highest resistance to penicillin.

Conclusions: Longer hospital stays were associated with older age (≥ 65 years), smoking, systemic diseases, type of treatment, involvement of multiple anatomical regions, and the need for additional surgery. Most of the cultured microorganisms were Staphylococcus species.

References

Ogle O . Odontogenic Infections. Dent Clin North Am. 2017; 61(2):235-252. DOI: 10.1016/j.cden.2016.11.004. View

Rasteniene R, Vitosyte M, Jankauskaite D, Aleksejuniene J . Predictors of longer hospitalization of maxillofacial infections-a 17-year retrospective study. Oral Dis. 2021; 28(7):1979-1986. DOI: 10.1111/odi.13894. View

Dym H, Zeidan J . Microbiology of Acute and Chronic Osteomyelitis and Antibiotic Treatment. Dent Clin North Am. 2017; 61(2):271-282. DOI: 10.1016/j.cden.2016.12.001. View

Yang B, Fang D, Lv Q, Wang Z, Liu Y . Targeted Therapeutic Strategies in the Battle Against Pathogenic Bacteria. Front Pharmacol. 2021; 12:673239. PMC: 8149751. DOI: 10.3389/fphar.2021.673239. View

Zawislak E, Nowak R . Odontogenic Head and Neck Region Infections Requiring Hospitalization: An 18-Month Retrospective Analysis. Biomed Res Int. 2021; 2021:7086763. PMC: 7834778. DOI: 10.1155/2021/7086763. View

Mathew G, Ranganathan L, Gandhi S, Jacob M, Singh I, Solanki M . Odontogenic maxillofacial space infections at a tertiary care center in North India: a five-year retrospective study. Int J Infect Dis. 2012; 16(4):e296-302. DOI: 10.1016/j.ijid.2011.12.014. View

Nadella K, Kodali R, Guttikonda L, Jonnalagadda A . Osteoradionecrosis of the Jaws: Clinico-Therapeutic Management: A Literature Review and Update. J Maxillofac Oral Surg. 2015; 14(4):891-901. PMC: 4648774. DOI: 10.1007/s12663-015-0762-9. View

Kun-Darbois J, Fauvel F . Medication-related osteonecrosis and osteoradionecrosis of the jaws: Update and current management. Morphologie. 2020; 105(349):170-187. DOI: 10.1016/j.morpho.2020.11.008. View

Dilalla V, Chaput G, Williams T, Sultanem K . Radiotherapy side effects: integrating a survivorship clinical lens to better serve patients. Curr Oncol. 2020; 27(2):107-112. PMC: 7253739. DOI: 10.3747/co.27.6233. View

10.

Sandmael J, Sand K, Bye A, Solheim T, Oldervoll L, Helvik A . Nutritional experiences in head and neck cancer patients. Eur J Cancer Care (Engl). 2019; 28(6):e13168. DOI: 10.1111/ecc.13168. View

11.

Thompson A, Anisimowicz Y, Miedema B, Hogg W, Wodchis W, Aubrey-Bassler K . The influence of gender and other patient characteristics on health care-seeking behaviour: a QUALICOPC study. BMC Fam Pract. 2016; 17:38. PMC: 4815064. DOI: 10.1186/s12875-016-0440-0. View

12.

Yuan F, Peng W, Yang C, Zheng J . Teriparatide versus bisphosphonates for treatment of postmenopausal osteoporosis: A meta-analysis. Int J Surg. 2019; 66:1-11. DOI: 10.1016/j.ijsu.2019.03.004. View

13.

Fliefel R, Troltzsch M, Kuhnisch J, Ehrenfeld M, Otto S . Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review. Int J Oral Maxillofac Surg. 2015; 44(5):568-85. DOI: 10.1016/j.ijom.2015.01.026. View

14.

Zaleckas L, Stacevicius M, Proskute D, Povilaityte J . Medication--related osteonecrosis of the jaws. The first reported cases in the Baltic States and a literature review. Stomatologija. 2016; 17(3):89-96. View

15.

Andre C, Khonsari R, Ernenwein D, Goudot P, Ruhin B . Osteomyelitis of the jaws: A retrospective series of 40 patients. J Stomatol Oral Maxillofac Surg. 2017; 118(5):261-264. DOI: 10.1016/j.jormas.2017.04.007. View

16.

Chukwulebe S, Hogrefe C . The Diagnosis and Management of Facial Bone Fractures. Emerg Med Clin North Am. 2018; 37(1):137-151. DOI: 10.1016/j.emc.2018.09.012. View

17.

Zaleckas L, Peciuliene V, Gendviliene I, Puriene A, Rimkuviene J . Prevalence and etiology of midfacial fractures: a study of 799 cases. Medicina (Kaunas). 2015; 51(4):222-7. DOI: 10.1016/j.medici.2015.06.005. View

18.

Ogle O . Salivary Gland Diseases. Dent Clin North Am. 2019; 64(1):87-104. DOI: 10.1016/j.cden.2019.08.007. View

19.

Karanfilian K, Valentin M, Kapila R, Bhate C, Fatahzadeh M, Micali G . Cervicofacial actinomycosis. Int J Dermatol. 2020; 59(10):1185-1190. DOI: 10.1111/ijd.14833. View

20.

Wong V, Turmezei T, Weston V . Actinomycosis. BMJ. 2011; 343:d6099. DOI: 10.1136/bmj.d6099. View