Alpha 2.0
Login Register
» Articles » PMID: 37288021

Evaluation of Saffron (Crocus Sativus L) Effects on Anxiety in Hospitalized Patients with Acute Coronary Syndrome

Overview
Journal Adv Biomed Res
Specialty Biomedical Engineering
Date 2023 Jun 8
PMID 37288021
Authors
Fariba Askari
Jamal Seidi
Mohammad Khaled Naqshbandi
Hajar Kashefi
Sholeh Shami
Affiliations
Soon will be listed here.
Abstract

Background: Anxiety is a common psychiatric condition in cardio-vascular diseases. Saffron appears to have a wide range of therapeutic effects on psychiatric conditions and cardio-vascular disorders. The aim of this study was to determine the effect of saffron on anxiety in hospitalized patients with acute coronary syndrome (ACS).

Materials And Methods: In this clinical investigation, we selected 80 patients with ACS from Tohid Medical Center, Sanandaj. Patients were divided randomly into two groups, intervention group ( = 41), and control group ( = 39), based on how they received saffron and placebo every 12 hours for 4 days, respectively. The Spielberger Anxiety Inventory was completed before and after the intervention in both groups.

Results: There was no significant difference between the intervention and control groups regarding the mean scores of the trait and state anxiety before and after the intervention ( > 0.05).

Conclusion: The present study did not corroborate the therapeutic effects of saffron on reducing anxiety in patients with ACS.

Citing Articles

Prevalence of anxiety and depression in patients with acute coronary syndrome: systematic review and meta-analysis.

Castro Mejia P, Cassano P, Moron P, Reategui M, Navarrete K, Cordova-Mendoza P Pan Afr Med J. 2024; 46:91.

PMID: 38405089 PMC: 10891371. DOI: 10.11604/pamj.2023.46.91.41792.

References
1.
Moazen-Zadeh E, Abbasi S, Safi-Aghdam H, Shahmansouri N, Arjmandi-Beglar A, Hajhosseinn Talasaz A . Effects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled Trial. J Altern Complement Med. 2017; 24(4):361-368. DOI: 10.1089/acm.2017.0173. View
2.
Hosseinzadeh H, Sadeghnia H . Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine. 2006; 14(4):256-62. DOI: 10.1016/j.phymed.2006.03.007. View
3.
Saki K, Bahmani M, Rafieian-Kopaei M . The effect of most important medicinal plants on two importnt psychiatric disorders (anxiety and depression)-a review. Asian Pac J Trop Med. 2014; 7S1:S34-42. DOI: 10.1016/S1995-7645(14)60201-7. View
4.
Halimeh A, Farhad R, Naseh S, Karim N . Comparative efficacy of honey 12.5% and chlorhexidine 0.2% mouthwashes on the oropharyngeal bacterial colonization in mechanically-ventilated patients: a randomized controlled trial. J Tradit Chin Med. 2020; 40(3):440-446. DOI: 10.19852/j.cnki.jtcm.2020.03.012. View
5.
Lopresti A, Drummond P . Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol. 2014; 29(6):517-27. DOI: 10.1002/hup.2434. View