Do Mindfulness-based Interventions Change Brain Function in People with Substance Dependence? A Systematic Review of the FMRI Evidence

Overview

Journal BMC Psychiatry

Publisher Biomed Central

Specialty Psychiatry

Date 2023 Jun 7

PMID 37286936

Authors

Valentina Lorenzetti

Alexandra Gaillard

Emillie Beyer

Magdalena Kowalczyk

Sunjeev K Kamboj

Victoria Manning

John Gleeson

Affiliations

Soon will be listed here.

Abstract

Background: Substance use disorders (SUDs) affect ~ 35 million people globally and are associated with strong cravings, stress, and brain alterations. Mindfulness-based interventions (MBIs) can mitigate the adverse psychosocial outcomes of SUDs, but the underlying neurobiology is unclear. Emerging findings were systematically synthesised from fMRI studies about MBI-associated changes in brain function in SUDs and their associations with mindfulness, drug quantity, and craving.

Methods: PsycINFO, Medline, CINAHL, PubMed, Scopus, and Web of Science were searched. Seven studies met inclusion criteria.

Results: Group by time effects indicated that MBIs in SUDs (6 tobacco and 1 opioid) were associated with changes in the function of brain pathways implicated in mindfulness and addiction (e.g., anterior cingulate cortex and striatum), which correlated with greater mindfulness, lower craving and drug quantity.

Conclusions: The evidence for fMRI-related changes with MBI in SUD is currently limited. More fMRI studies are required to identify how MBIs mitigate and facilitate recovery from aberrant brain functioning in SUDs.

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References

Gibson J . Mindfulness, Interoception, and the Body: A Contemporary Perspective. Front Psychol. 2019; 10:2012. PMC: 6753170. DOI: 10.3389/fpsyg.2019.02012. View

Zhai T, Salmeron B, Gu H, Adinoff B, Stein E, Yang Y . Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse: implications for neuromodulation treatment. Brain Commun. 2021; 3(2):fcab120. PMC: 8226190. DOI: 10.1093/braincomms/fcab120. View

Creswell J, Way B, Eisenberger N, Lieberman M . Neural correlates of dispositional mindfulness during affect labeling. Psychosom Med. 2007; 69(6):560-5. DOI: 10.1097/PSY.0b013e3180f6171f. View

Tang Y, Tang R, Posner M . Brief meditation training induces smoking reduction. Proc Natl Acad Sci U S A. 2013; 110(34):13971-5. PMC: 3752264. DOI: 10.1073/pnas.1311887110. View

Naqvi N, Gaznick N, Tranel D, Bechara A . The insula: a critical neural substrate for craving and drug seeking under conflict and risk. Ann N Y Acad Sci. 2014; 1316:53-70. PMC: 4114146. DOI: 10.1111/nyas.12415. View

Cheng W, Rolls E, Robbins T, Gong W, Liu Z, Lv W . Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. Elife. 2019; 8. PMC: 6336408. DOI: 10.7554/eLife.40765. View

Kober H, Brewer J, Height K, Sinha R . Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments. Neuroimage. 2016; 151:4-13. PMC: 5373945. DOI: 10.1016/j.neuroimage.2016.09.042. View

Droutman V, Read S, Bechara A . Revisiting the role of the insula in addiction. Trends Cogn Sci. 2015; 19(7):414-20. PMC: 4486609. DOI: 10.1016/j.tics.2015.05.005. View

Fox K, Nijeboer S, Dixon M, Floman J, Ellamil M, Rumak S . Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners. Neurosci Biobehav Rev. 2014; 43:48-73. DOI: 10.1016/j.neubiorev.2014.03.016. View

10.

Sharp P, Sutton B, Paul E, Sherepa N, Hillman C, Cohen N . Mindfulness training induces structural connectome changes in insula networks. Sci Rep. 2018; 8(1):7929. PMC: 5962606. DOI: 10.1038/s41598-018-26268-w. View

11.

Kamboj S, Irez D, Serfaty S, Thomas E, Das R, Freeman T . Ultra-Brief Mindfulness Training Reduces Alcohol Consumption in At-Risk Drinkers: A Randomized Double-Blind Active-Controlled Experiment. Int J Neuropsychopharmacol. 2017; 20(11):936-947. PMC: 5737497. DOI: 10.1093/ijnp/pyx064. View

12.

Brewer J, Garrison K, Whitfield-Gabrieli S . What about the "Self" is Processed in the Posterior Cingulate Cortex?. Front Hum Neurosci. 2013; 7:647. PMC: 3788347. DOI: 10.3389/fnhum.2013.00647. View

13.

Kozink R, Kollins S, McClernon F . Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control. Neuropsychopharmacology. 2010; 35(13):2600-6. PMC: 2978758. DOI: 10.1038/npp.2010.154. View

14.

Brewer J, Garrison K . The posterior cingulate cortex as a plausible mechanistic target of meditation: findings from neuroimaging. Ann N Y Acad Sci. 2013; 1307:19-27. DOI: 10.1111/nyas.12246. View

15.

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. PMC: 8005924. DOI: 10.1136/bmj.n71. View

16.

Garland E, Froeliger B, Howard M . Mindfulness training targets neurocognitive mechanisms of addiction at the attention-appraisal-emotion interface. Front Psychiatry. 2014; 4:173. PMC: 3887509. DOI: 10.3389/fpsyt.2013.00173. View

17.

Janes A, Datko M, Roy A, Barton B, Druker S, Neal C . Quitting starts in the brain: a randomized controlled trial of app-based mindfulness shows decreases in neural responses to smoking cues that predict reductions in smoking. Neuropsychopharmacology. 2019; 44(9):1631-1638. PMC: 6785102. DOI: 10.1038/s41386-019-0403-y. View

18.

Jarraya B, Brugieres P, Tani N, Hodel J, Grandjacques B, Fenelon G . Disruption of cigarette smoking addiction after posterior cingulate damage. J Neurosurg. 2010; 113(6):1219-21. DOI: 10.3171/2010.6.JNS10346. View

19.

Gilman J, Radoman M, Schuster R, Pachas G, Azzouz N, Fava M . Anterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinence. Addict Behav Rep. 2018; 7:40-46. PMC: 5805503. DOI: 10.1016/j.abrep.2018.01.002. View

20.

van der Meer L, Costafreda S, Aleman A, David A . Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neurosci Biobehav Rev. 2009; 34(6):935-46. DOI: 10.1016/j.neubiorev.2009.12.004. View