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Gut Microbiota Bridges Dietary Nutrients and Host Immunity

Abstract

Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other, and thus affect host health and immune-mediated diseases. Here, we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions, emphasizing how this axis might influence host immunity in health and diseases. Of relevance, we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.

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References
1.
Jasim S, Catalan Opulencia M, Ramirez-Coronel A, Abdelbasset W, Hasan Abed M, Markov A . The emerging role of microbiota-derived short-chain fatty acids in immunometabolism. Int Immunopharmacol. 2022; 110:108983. DOI: 10.1016/j.intimp.2022.108983. View

2.
Abe R, Masroor A, Khorochkov A, Prieto J, Singh K, Nnadozie M . The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review. Cureus. 2021; 13(8):e16855. PMC: 8424975. DOI: 10.7759/cureus.16855. View

3.
Abidin M, Saravanan T, Zhang J, Tepper P, Strauss E, Poelarends G . Modular Enzymatic Cascade Synthesis of Vitamin B and Its Derivatives. Chemistry. 2018; 24(66):17434-17438. PMC: 6471175. DOI: 10.1002/chem.201804151. View

4.
Akkerman R, Faas M, de Vos P . Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: Effects on microbiota and gut maturation. Crit Rev Food Sci Nutr. 2018; 59(9):1486-1497. DOI: 10.1080/10408398.2017.1414030. View

5.
Al-Bulish M, Cao W, Yang R, Wang Y, Xue C, Tang Q . Docosahexaenoic acid-rich fish oil alleviates hepatic steatosis in association with regulation of gut microbiome in ob/ob mice. Food Res Int. 2022; 157:111373. DOI: 10.1016/j.foodres.2022.111373. View