Regulation of Endothelial Function by Cigarette Smoke and Next-generation Tobacco and Nicotine Products

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2023 Jun 7

PMID 37285061

Authors

Justus Klein

Patrick Diaba-Nuhoho

Sindy Giebe

Coy Brunssen

Henning Morawietz

Affiliations

Soon will be listed here.

Abstract

Cigarette smoking is the most important avoidable cardiovascular risk factor. It causes endothelial dysfunction and atherosclerosis and increases the risk of its severe clinical complications like coronary artery disease, myocardial infarction, stroke, and peripheral artery disease. Several next-generation tobacco and nicotine products have been developed to decrease some of the deleterious effects of regular tobacco smoking. This review article summarizes recent findings about the impact of cigarette smoking and next-generation tobacco and nicotine products on endothelial dysfunction. Both cigarette smoking and next-generation tobacco products lead to impaired endothelial function. Molecular mechanisms of endothelial dysfunction like oxidative stress, reduced nitric oxide availability, inflammation, increased monocyte adhesion, and cytotoxic effects of cigarette smoke and next-generation tobacco and nicotine products are highlighted. The potential impact of short- and long-term exposure to next-generation tobacco and nicotine products on the development of endothelial dysfunction and its clinical implications for cardiovascular diseases are discussed.

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References

Jin L, Jagatheesan G, Lynch J, Guo L, Conklin D . Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1). Toxicol Appl Pharmacol. 2020; 398:115012. PMC: 7375699. DOI: 10.1016/j.taap.2020.115012. View

Chen H, Lii C, Ku H, Wang T . Cigarette smoke extract induces expression of cell adhesion molecules in HUVEC via actin filament reorganization. Environ Mol Mutagen. 2008; 50(2):96-104. DOI: 10.1002/em.20441. View

Makwana O, Flockton H, Smith G, Watters G, Nisar R, Fields W . Mechanisms of whole smoke conditioned media induced cytotoxicity to human aortic endothelial cells. Toxicol In Vitro. 2019; 58:239-244. DOI: 10.1016/j.tiv.2019.03.011. View

Pieper E, Mallock N, Henkler-Stephani F, Luch A . ["Heat not burn" tobacco devices as new tobacco industry products: health risks]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018; 61(11):1422-1428. DOI: 10.1007/s00103-018-2823-y. View

Cooke J . New Insights Into Tobacco-Induced Vascular Disease: Clinical Ramifications. Methodist Debakey Cardiovasc J. 2015; 11(3):156-9. PMC: 4666421. DOI: 10.14797/mdcj-11-3-156. View

Csordas A, Bernhard D . The biology behind the atherothrombotic effects of cigarette smoke. Nat Rev Cardiol. 2013; 10(4):219-30. DOI: 10.1038/nrcardio.2013.8. View

Schaller J, Pijnenburg J, Ajithkumar A, Tricker A . Evaluation of the Tobacco Heating System 2.2. Part 3: Influence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol. Regul Toxicol Pharmacol. 2016; 81 Suppl 2:S48-S58. DOI: 10.1016/j.yrtph.2016.10.016. View

Srivastava S, Sithu S, Vladykovskaya E, Haberzettl P, Hoetker D, Siddiqui M . Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice. Atherosclerosis. 2011; 215(2):301-8. PMC: 3070047. DOI: 10.1016/j.atherosclerosis.2011.01.001. View

Mallock N, Boss L, Burk R, Danziger M, Welsch T, Hahn H . Levels of selected analytes in the emissions of "heat not burn" tobacco products that are relevant to assess human health risks. Arch Toxicol. 2018; 92(6):2145-2149. PMC: 6002459. DOI: 10.1007/s00204-018-2215-y. View

10.

Abplanalp W, DeJarnett N, Riggs D, Conklin D, McCracken J, Srivastava S . Benzene exposure is associated with cardiovascular disease risk. PLoS One. 2017; 12(9):e0183602. PMC: 5590846. DOI: 10.1371/journal.pone.0183602. View

11.

Horinouchi T, Miwa S . Comparison of cytotoxicity of cigarette smoke extract derived from heat-not-burn and combustion cigarettes in human vascular endothelial cells. J Pharmacol Sci. 2021; 147(3):223-233. DOI: 10.1016/j.jphs.2021.07.005. View

12.

Smith C, Fischer T . Particulate and vapor phase constituents of cigarette mainstream smoke and risk of myocardial infarction. Atherosclerosis. 2001; 158(2):257-67. DOI: 10.1016/s0021-9150(01)00570-6. View

13.

Risi S . On the Origins of the Electronic Cigarette: British American Tobacco's Project Ariel (1962-1967). Am J Public Health. 2017; 107(7):1060-1067. PMC: 5463218. DOI: 10.2105/AJPH.2017.303806. View

14.

Thun M, Heath Jr C . Changes in mortality from smoking in two American Cancer Society prospective studies since 1959. Prev Med. 1997; 26(4):422-6. DOI: 10.1006/pmed.1997.0182. View

15.

Newby A . Metalloproteinases and vulnerable atherosclerotic plaques. Trends Cardiovasc Med. 2007; 17(8):253-8. PMC: 2850988. DOI: 10.1016/j.tcm.2007.09.001. View

16.

Meng X, Guo X, Peng Z, Wang C, Liu R . Acute effects of electronic cigarettes on vascular endothelial function: a systematic review and meta-analysis of randomized controlled trials. Eur J Prev Cardiol. 2022; 30(5):425-435. DOI: 10.1093/eurjpc/zwac248. View

17.

Ding Y, Ashley D, Watson C . Determination of 10 carcinogenic polycyclic aromatic hydrocarbons in mainstream cigarette smoke. J Agric Food Chem. 2007; 55(15):5966-73. DOI: 10.1021/jf070649o. View

18.

Pulliero A, Godschalk R, Andreassi M, Curfs D, Schooten F, Izzotti A . Environmental carcinogens and mutational pathways in atherosclerosis. Int J Hyg Environ Health. 2015; 218(3):293-312. DOI: 10.1016/j.ijheh.2015.01.007. View

19.

Cacciola R, Guarino F, Polosa R . Relevance of endothelial-haemostatic dysfunction in cigarette smoking. Curr Med Chem. 2007; 14(17):1887-92. DOI: 10.2174/092986707781058832. View

20.

Kritz H, Schmid P, Sinzinger H . Passive smoking and cardiovascular risk. Arch Intern Med. 1995; 155(18):1942-8. View