Vertical Transmission of HIV to Neonates in a Reference Hospital in Northeastern Brazil from 2013 to 2017

Overview

Journal Rev Inst Med Trop Sao Paulo

Specialty Tropical Medicine

Date 2023 Jun 7

PMID 37283409

Authors

Vaneca Santos Leal Figueredo

Denise Leite Maia Monteiro

Rosangela Fernandes Lucena Batista

Monica Elinor Alves Gama

Aline Santos Furtado Campos

Adna Gesarone Carvalho Ferreira Pinto

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to estimate the rate of Mother-to-child Transmission (MTCT) of HIV to neonates in a reference university hospital in Sao Luis city, the capital of Maranhao State (MA), evaluating MTCT-associated factors. A retrospective cohort study based on data from the Notifiable Diseases Data System (SINAN) was carried out and included all HIV-exposed neonates notified from 2013 to 2017 by the university hospital. The study population comprised 725 HIV-exposed neonates, of whom 672 neonates were exposed and uninfected, and 53 were exposed and infected. The estimated rate of MTCT in the period of 2013 to 2017 was 7.3%. Most pregnant women were ≥ 20 years old (86.9%), reported ≥ 8 years of schooling (53.2%), reported full-time or independent paid work (46.9%) and were residents in other cities of the state (61.7%). Regarding healthcare, 86.3% received prenatal care, 74.6% received Antiretroviral Therapy (ART) as prophylaxis during pregnancy, 81.8% received ART prophylaxis during childbirth and 78.1% underwent cesarean section. Among the neonates, 92.8% received ART prophylaxis and 94.3% were not breastfed. Despite these variables, the 7.3% MTCT rate found in this study makes it clear that the interventions recommended by the Ministry of Health were not fully adopted.

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