Non-lethal Outcomes of Engaging Regulated Cell Death Pathways in Cancer

Overview

Journal Nat Cancer

Specialty Oncology

Date 2023 Jun 5

PMID 37277528

Authors

Halime Kalkavan

Sebastian Ruhl

Jeremy J P Shaw

Douglas R Green

Affiliations

Soon will be listed here.

Abstract

Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the engagement of RCD pathways does not inevitably result in cell death. Instead, RCD pathways can take part in diverse biological processes if the cells survive. Consequently, these surviving cells, for which we propose the term 'flatliners', harbor important functions. These evolutionarily conserved responses can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.

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