Maintaining Chromosome and Genome Stability by the RPA-RNF20-SNF2H Cascade

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2023 Jun 5

PMID 37276422

Authors

Garrett Driscoll

Shan Yan

Affiliations

Soon will be listed here.

References

Anjur-Dietrich M, Kelleher C, Needleman D . Mechanical Mechanisms of Chromosome Segregation. Cells. 2021; 10(2). PMC: 7926803. DOI: 10.3390/cells10020465. View

Bass T, Luzwick J, Kavanaugh G, Carroll C, Dungrawala H, Glick G . ETAA1 acts at stalled replication forks to maintain genome integrity. Nat Cell Biol. 2016; 18(11):1185-1195. PMC: 5245861. DOI: 10.1038/ncb3415. View

Yan S, Sorrell M, Berman Z . Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cell Mol Life Sci. 2014; 71(20):3951-67. PMC: 4176976. DOI: 10.1007/s00018-014-1666-4. View

Caldwell C, Spies M . Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair. Crit Rev Biochem Mol Biol. 2020; 55(5):482-507. PMC: 7821911. DOI: 10.1080/10409238.2020.1813070. View

Zhou S, Cai Y, Liu X, Jin L, Wang X, Ma W . Role of H2B mono-ubiquitination in the initiation and progression of cancer. Bull Cancer. 2021; 108(4):385-398. DOI: 10.1016/j.bulcan.2020.12.007. View

Carmena M, Wheelock M, Funabiki H, Earnshaw W . The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012; 13(12):789-803. PMC: 3729939. DOI: 10.1038/nrm3474. View

Oss-Ronen L, Sarusi T, Cohen I . Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease. Cells. 2022; 11(15). PMC: 9368181. DOI: 10.3390/cells11152404. View

Chernikova S, Razorenova O, Higgins J, Sishc B, Nicolau M, Dorth J . Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res. 2012; 72(8):2111-9. PMC: 3328627. DOI: 10.1158/0008-5472.CAN-11-2209. View

Tanaka K . Regulatory mechanisms of kinetochore-microtubule interaction in mitosis. Cell Mol Life Sci. 2012; 70(4):559-79. PMC: 11113415. DOI: 10.1007/s00018-012-1057-7. View

10.

Wang E, Kawaoka S, Yu M, Shi J, Ni T, Yang W . Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A. 2013; 110(10):3901-6. PMC: 3593849. DOI: 10.1073/pnas.1301045110. View

11.

Liu G, Yan J, Wang X, Chen J, Wang X, Dong Y . RPA-mediated recruitment of Bre1 couples histone H2B ubiquitination to DNA replication and repair. Proc Natl Acad Sci U S A. 2021; 118(8). PMC: 7923545. DOI: 10.1073/pnas.2017497118. View

12.

Sekiguchi M, Matsushita N . DNA Damage Response Regulation by Histone Ubiquitination. Int J Mol Sci. 2022; 23(15). PMC: 9332593. DOI: 10.3390/ijms23158187. View

13.

Sethi G, Shanmugam M, Arfuso F, Kumar A . Role of RNF20 in cancer development and progression - a comprehensive review. Biosci Rep. 2018; 38(4). PMC: 6043722. DOI: 10.1042/BSR20171287. View

14.

Broad A, DeLuca K, DeLuca J . Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells. J Cell Biol. 2020; 219(3). PMC: 7055008. DOI: 10.1083/jcb.201905144. View

15.

Ma H, Poon R . Aurora kinases and DNA damage response. Mutat Res. 2020; 821:111716. DOI: 10.1016/j.mrfmmm.2020.111716. View

16.

Kabeche L, Nguyen H, Buisson R, Zou L . A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation. Science. 2017; 359(6371):108-114. PMC: 5875943. DOI: 10.1126/science.aan6490. View

17.

Shiloh Y, Shema E, Moyal L, Oren M . RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response. FEBS Lett. 2011; 585(18):2795-802. DOI: 10.1016/j.febslet.2011.07.034. View

18.

Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang S . Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell. 2011; 41(5):529-42. PMC: 3397146. DOI: 10.1016/j.molcel.2011.02.015. View

19.

So C, Ramachandran S, Martin A . E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair. Mol Cell Biol. 2019; 39(8). PMC: 6447412. DOI: 10.1128/MCB.00488-18. View

20.

Li J, Zhao J, Gan X, Wang Y, Jiang D, Chen L . The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair. Proc Natl Acad Sci U S A. 2023; 120(20):e2303479120. PMC: 10193940. DOI: 10.1073/pnas.2303479120. View