Functional Near-infrared Spectroscopy Neurofeedback of Dorsolateral Prefrontal Cortex Enhances Human Spatial Working Memory

Overview

Journal Neurophotonics

Date 2023 Jun 5

PMID 37275655

Authors

Keshuang Li

Jinhao Yang

Benjamin Becker

Xianchun Li

Affiliations

Soon will be listed here.

Abstract

Significance: Spatial working memory (SWM) is essential for daily life and deficits in this domain represent a common impairment across aging and several mental disorders. Impaired SWM has been closely linked to dysregulations in dorsolateral prefrontal cortex (DLPFC) activation.

Aim: The present study evaluates the feasibility and maintenance of functional near-infrared spectroscopy neurofeedback (fNIRS-NF) training of the DLPFC to enhance SWM in healthy individuals using a real-time fNIRS-NF platform developed by the authors.

Approach: We used a randomized sham-controlled between-subject fNIRS-NF design with 60 healthy subjects as a sample. Training-induced changes in the DLPFC, SWM, and attention performance served as primary outcomes.

Results: Feedback from the target channel significantly increased regional-specific DLPFC activation over the fNIRS-NF training compared to sham NF. A significant group difference in NF-induced frontoparietal connectivity was observed. Compared to the control group, the experimental group demonstrated significantly improved SWM and attention performance that were maintained for 1 week. Furthermore, a mediation analysis demonstrated that increased DLPFC activation mediated the effects of fNIRS-NF treatment on better SWM performance.

Conclusions: The present results demonstrated that successful self-regulation of DLPFC activation may represent a long-lasting intervention to improve human SWM and has the potential for further applications.

Citing Articles

Differential features of early childhood motor skill development and working memory processing: evidence from fNIRS.

Zheng Q, Chi A, Shi B, Wang Y, Ma Q, Zhou F Front Behav Neurosci. 2023; 17:1279648.

PMID: 37840544 PMC: 10574188. DOI: 10.3389/fnbeh.2023.1279648.

References

Huppert T . Commentary on the statistical properties of noise and its implication on general linear models in functional near-infrared spectroscopy. Neurophotonics. 2016; 3(1):010401. PMC: 4773699. DOI: 10.1117/1.NPh.3.1.010401. View

Wagner S, Muller C, Helmreich I, Huss M, Tadic A . A meta-analysis of cognitive functions in children and adolescents with major depressive disorder. Eur Child Adolesc Psychiatry. 2014; 24(1):5-19. DOI: 10.1007/s00787-014-0559-2. View

Yang X, Zeng Y, Jiao G, Gan X, Linden D, Hernaus D . A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge. Prog Neuropsychopharmacol Biol Psychiatry. 2024; 132:110968. DOI: 10.1016/j.pnpbp.2024.110968. View

Dekker M, Sitskoorn M, Denissen A, van Boxtel G . The time-course of alpha neurofeedback training effects in healthy participants. Biol Psychol. 2013; 95:70-3. DOI: 10.1016/j.biopsycho.2013.11.014. View

Wilde N, Strauss E . Functional equivalence of WAIS-III/WMS-III digit and spatial span under forward and backward recall conditions. Clin Neuropsychol. 2003; 16(3):322-30. DOI: 10.1076/clin.16.3.322.13858. View

Fales C, Barch D, Rundle M, Mintun M, Snyder A, Cohen J . Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression. Biol Psychiatry. 2007; 63(4):377-84. PMC: 2268639. DOI: 10.1016/j.biopsych.2007.06.012. View

Salmi J, Soveri A, Salmela V, Alho K, Leppamaki S, Tani P . Working memory training restores aberrant brain activity in adult attention-deficit hyperactivity disorder. Hum Brain Mapp. 2020; 41(17):4876-4891. PMC: 7643386. DOI: 10.1002/hbm.25164. View

Thibault R, Macpherson A, Lifshitz M, Roth R, Raz A . Neurofeedback with fMRI: A critical systematic review. Neuroimage. 2017; 172:786-807. DOI: 10.1016/j.neuroimage.2017.12.071. View

Sala-Llonch R, Pena-Gomez C, Arenaza-Urquijo E, Vidal-Pineiro D, Bargallo N, Junque C . Brain connectivity during resting state and subsequent working memory task predicts behavioural performance. Cortex. 2011; 48(9):1187-96. DOI: 10.1016/j.cortex.2011.07.006. View

10.

Gamo N, Arnsten A . Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders. Behav Neurosci. 2011; 125(3):282-96. PMC: 3109197. DOI: 10.1037/a0023165. View

11.

Liu J, Zhang R, Geng B, Zhang T, Yuan D, Otani S . Interplay between prior knowledge and communication mode on teaching effectiveness: Interpersonal neural synchronization as a neural marker. Neuroimage. 2019; 193:93-102. DOI: 10.1016/j.neuroimage.2019.03.004. View

12.

Smallwood J, OConnor R . Imprisoned by the past: unhappy moods lead to a retrospective bias to mind wandering. Cogn Emot. 2011; 25(8):1481-90. DOI: 10.1080/02699931.2010.545263. View

13.

Hou X, Xiao X, Gong Y, Li Z, Chen A, Zhu C . Functional Near-Infrared Spectroscopy Neurofeedback Enhances Human Spatial Memory. Front Hum Neurosci. 2021; 15:681193. PMC: 8511425. DOI: 10.3389/fnhum.2021.681193. View

14.

Reindl V, Gerloff C, Scharke W, Konrad K . Brain-to-brain synchrony in parent-child dyads and the relationship with emotion regulation revealed by fNIRS-based hyperscanning. Neuroimage. 2018; 178:493-502. DOI: 10.1016/j.neuroimage.2018.05.060. View

15.

Wu Y, Tseng P, Chang C, Pai M, Hsu K, Lin C . Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex. Brain Cogn. 2014; 91:87-94. DOI: 10.1016/j.bandc.2014.09.002. View

16.

Kerchner G, Racine C, Hale S, Wilheim R, Laluz V, Miller B . Cognitive processing speed in older adults: relationship with white matter integrity. PLoS One. 2012; 7(11):e50425. PMC: 3503892. DOI: 10.1371/journal.pone.0050425. View

17.

Kronovsek T, Hermand E, Berthoz A, Castilla A, Gallou-Guyot M, Daviet J . Age-related decline in visuo-spatial working memory is reflected by dorsolateral prefrontal activation and cognitive capabilities. Behav Brain Res. 2020; 398:112981. DOI: 10.1016/j.bbr.2020.112981. View

18.

Silk T, Rinehart N, Bradshaw J, Tonge B, Egan G, OBoyle M . Visuospatial processing and the function of prefrontal-parietal networks in autism spectrum disorders: a functional MRI study. Am J Psychiatry. 2006; 163(8):1440-3. DOI: 10.1176/ajp.2006.163.8.1440. View

19.

Guevara M, Cruz Paniagua E, Gonzalez M, Sandoval Carrillo I, Almanza Sepulveda M, Hevia Orozco J . EEG activity during the spatial span task in young men: Differences between short-term and working memory. Brain Res. 2018; 1683:86-94. DOI: 10.1016/j.brainres.2018.02.004. View

20.

Haugg A, Sladky R, Skouras S, McDonald A, Craddock C, Kirschner M . Can we predict real-time fMRI neurofeedback learning success from pretraining brain activity?. Hum Brain Mapp. 2020; 41(14):3839-3854. PMC: 7469782. DOI: 10.1002/hbm.25089. View