Efficacy of Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Rectal Neuroendocrine Tumors ≤10mm: a Systematic Review and Meta-analysis

Overview

Journal Ann Saudi Med

Specialty General Medicine

Date 2023 Jun 4

PMID 37270677

Authors

Ce Zhou

Furong Zhang

Yinghua We

Affiliations

Soon will be listed here.

Abstract

Background: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are surgical methods used for rectal neuroendocrine tumors (NETs) with diameters of ≤ 10 mm. However, which method has a higher performance remains uncertain.

Objectives: Evaluate which of the two methods shows a higher performance.

Design: Systematic review and meta-analysis METHODS: Data from PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to 12 April 2022. Outcomes, including complete resection, en bloc resection, recurrence, perforation, bleeding, and procedure time, were pooled by 95% confidence intervals (95% CI) using a fixed- or random-effects model.

Main Outcome Measures: Complete resection, en bloc resection, and recurrence.

Sample Size: 18 studies, including 1168 patients were included in the study.

Results: Eighteen retrospective cohort studies were included in this meta-analysis. There were no statistical differences in the rates of complete resection, en bloc resection, recurrence, perforation, and bleeding rates between EMR and ESD. However, a statistical difference was detected in the procedure time; EMR had a significantly shorter time (MD=-17.47, 95% CI=-22.31 - -12.62, <.00001).

Conclusions: EMR and ESD had similar efficacies and safety profiles in resectioning rectal NETs ≤ 10 mm. Even so, the advantages of EMR included a shorter operation time and expenditure. Thus, with respect to health economics, EMR outperformed ESD.

Limitation: Most of these studies are retrospective cohort studies instead of RCTs.

Conflict Of Interest: None.

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