Association Between Single Nucleotide Polymorphisms in DNA Repair Genes and the Efficacy of Radiotherapy in Nasopharyngeal Carcinoma Patients

Overview

Journal Contemp Oncol (Pozn)

Publisher Termedia

Specialty Oncology

Date 2023 Jun 2

PMID 37266339

Authors

Rajaa Benzeid

Amin Gihbid

Nezha Tawfik

Nadia Benchakroun

Karima Bendahhou

Abdellatif Benider

Amal Guensi

Naima El Benna

Abdelkarim Filali Maltouf

Mohammed El Mzibri

Mohammed Attaleb

Meriem Khyatti

Imane Chaoui

Affiliations

Soon will be listed here.

Abstract

Introduction: Single nucleotide polymorphisms (SNPs) in DNA repair genes are mainly correlated with the response to radiotherapy in nasopharyngeal cancer (NPC). In NPC patients, previous research has studied the association between X-ray repair cross-complementing group 1 and 3 (XRCC1 and XRCC3) polymorphisms and radio-therapeutic response. The objective of our study was to test the association between XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms and the response to radiotherapy in the NPC Moroccan population.

Material And Methods: A total of 100 patients with NPC were genotyped for polymorphisms in XRCC1 and XRCC3 genes.

Results: The results revealed that the genotypes and alleles of both SNPs did not show any significant association with clinical stages (for XRCC1 Arg399Gln: [genotype] = 0.559; [allele] = 0.440) and (for XRCC3 Thr241Met: [genotype] = 0.638; [allele] = 0.567). Moreover, in the study of the association between the polymorphisms and radiotherapy, the response to radiation therapy between genotypes and alleles was not statistically significant (for XRCC1 Arg399Gln p [genotype] = 0.583; p [allele] = 0.459) and (for XRCC3 Thr241Met [genotype] = 0.660; [allele] = 0.590).

Conclusions: The present study suggests that XRCC1 Arg399Gln polymorphism does not have any impact on the radio-therapeutic response in Moroccan NPC patients whereas XRCC3 Thr241Met polymorphism may act as a prognostic indicator for NPC patients treated with radiotherapy. However, studies with a larger sample are needed to confirm our results.

References

Liu Z, Chen Y, Su Y, Hu X, Peng X . Nasopharyngeal Carcinoma: Clinical Achievements and Considerations Among Treatment Options. Front Oncol. 2021; 11:635737. PMC: 8667550. DOI: 10.3389/fonc.2021.635737. View

Wood R, Mitchell M, Sgouros J, Lindahl T . Human DNA repair genes. Science. 2001; 291(5507):1284-9. DOI: 10.1126/science.1056154. View

Pereira J, Fontes F, Batistuzzo de Medeiros S, Freitas R, de Souza L, da Costa Miguel M . Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. Arch Oral Biol. 2016; 64:19-23. DOI: 10.1016/j.archoralbio.2015.12.004. View

Soliman A, Zaki N, Fathy H, Mohamed A, Ezzat M, Rayan A . Genetic polymorphisms in XRCC1, OGG1, and XRCC3 DNA repair genes and DNA damage in radiotherapy workers. Environ Sci Pollut Res Int. 2020; 27(35):43786-43799. DOI: 10.1007/s11356-020-10270-9. View

Huang R, Zhou P . DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transduct Target Ther. 2020; 5(1):60. PMC: 7192953. DOI: 10.1038/s41392-020-0150-x. View

Chen H, Wu M, Li G, Hua L, Chen S, Huang H . Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study. Medicine (Baltimore). 2017; 96(44):e8202. PMC: 5682770. DOI: 10.1097/MD.0000000000008202. View

Santos R, Teixeira A, Mayorano M, Carrara H, Andrade J, Takahashi C . DNA repair genes XRCC1 and XRCC3 polymorphisms and their relationship with the level of micronuclei in breast cancer patients. Genet Mol Biol. 2011; 33(4):637-40. PMC: 3036161. DOI: 10.1590/S1415-47572010005000082. View

Qiu M, Xu L, Yang X, Ding X, Hu J, Jiang F . XRCC3 Thr241Met is associated with response to platinum-based chemotherapy but not survival in advanced non-small cell lung cancer. PLoS One. 2013; 8(10):e77005. PMC: 3792919. DOI: 10.1371/journal.pone.0077005. View

Tang L, Wei F, Wu Y, He Y, Shi L, Xiong F . Role of metabolism in cancer cell radioresistance and radiosensitization methods. J Exp Clin Cancer Res. 2018; 37(1):87. PMC: 5914062. DOI: 10.1186/s13046-018-0758-7. View

10.

Jin H, Xie X, Wang H, Hu J, Liu F, Liu Z . ERCC1 Cys8092Ala and XRCC1 Arg399Gln polymorphisms predict progression-free survival after curative radiotherapy for nasopharyngeal carcinoma. PLoS One. 2014; 9(7):e101256. PMC: 4099069. DOI: 10.1371/journal.pone.0101256. View

11.

Osti M, Nicosia L, Agolli L, Gentile G, Falco T, Bracci S . Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy. Am J Clin Oncol. 2015; 40(6):535-542. DOI: 10.1097/COC.0000000000000182. View

12.

Wang J, Wang H, Qian H . Biological effects of radiation on cancer cells. Mil Med Res. 2018; 5(1):20. PMC: 6026344. DOI: 10.1186/s40779-018-0167-4. View

13.

Zhao Y, Xie Y, Jia D, Ma C, Wei D, Zhang X . Application of gene polymorphisms to predict the sensitivity of patients with locally advanced non-small cell lung cancer undergoing chemoradiotherapy. Am J Transl Res. 2021; 13(6):7382-7387. PMC: 8290768. View

14.

Liu Y, Zheng C, Huang Y, He M, Xu W, Li B . Molecular mechanisms of chemo- and radiotherapy resistance and the potential implications for cancer treatment. MedComm (2020). 2021; 2(3):315-340. PMC: 8554658. DOI: 10.1002/mco2.55. View

15.

Langsenlehner T, Renner W, Gerger A, Hofmann G, Thurner E, Kapp K . Association between single nucleotide polymorphisms in the gene for XRCC1 and radiation-induced late toxicity in prostate cancer patients. Radiother Oncol. 2011; 98(3):387-93. DOI: 10.1016/j.radonc.2011.01.021. View

16.

Chang-Claude J, Popanda O, Tan X, Kropp S, Helmbold I, von Fournier D . Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res. 2005; 11(13):4802-9. DOI: 10.1158/1078-0432.CCR-04-2657. View

17.

Siak P, Khoo A, Leong C, Hoh B, Cheah S . Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma. Cancers (Basel). 2021; 13(14). PMC: 8305767. DOI: 10.3390/cancers13143490. View

18.

Burri R, Stock R, Cesaretti J, Atencio D, Peters S, Peters C . Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. Radiat Res. 2008; 170(1):49-59. DOI: 10.1667/RR1219.1. View

19.

Nanda S, Gandhi A, Rastogi M, Khurana R, Hadi R, Sahni K . Evaluation of XRCC1 Gene Polymorphism as a Biomarker in Head and Neck Cancer Patients Undergoing Chemoradiation Therapy. Int J Radiat Oncol Biol Phys. 2018; 101(3):593-601. DOI: 10.1016/j.ijrobp.2018.03.039. View

20.

Narter K, Ergen A, Agachan B, Gormus U, Timirci O, Isbir T . Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). Anticancer Res. 2009; 29(4):1389-93. View