Therapeutic Applications of Contact Lens-based Drug Delivery Systems in Ophthalmic Diseases

Overview

Journal Drug Deliv

Specialty Pharmacology

Date 2023 Jun 2

PMID 37264930

Authors

Lianghui Zhao

Jike Song

Yongle Du

Cong Ren

Bin Guo

Hongsheng Bi

Affiliations

Soon will be listed here.

Abstract

Traditional ophthalmic drugs, such as eye drops, gels and ointments, are accompanied by many problems, including low bioavailability and potential drug side effects. Innovative ophthalmic drug delivery systems have been proposed to overcome the limitations associated with traditional formulations. Recently, contact lens-based drug delivery systems have gained popularity owing to their advantages of sustained drug delivery, prolonged drug retention, improved bioavailability, and few drug side effects. Various methods have been successfully applied to drug-loaded contact lenses and prolonged the drug release time, such as chemical crosslinking, material embedding, molecular imprinting, colloidal nanoparticles, vitamin E modification, drug polymer film/coating, ion ligand polymerization systems, and supercritical fluid technology. Contact lens-based drug delivery systems play an important role in the treatment of multifarious ophthalmic diseases. This review discusses the latest developments in drug-loaded contact lenses for the treatment of ophthalmic diseases, including preparation methods, application in ophthalmic diseases and future prospects.

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