Advances in Understanding Infections Caused by the Basal Fungus Mucor

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2023 Jun 1

PMID 37262085

Authors

Jose T Canovas-Marquez

Carlos Lax

Ghizlane Tahiri

Eusebio Navarro

Francisco E Nicolas

Victoriano Garre

Affiliations

Soon will be listed here.

References

Kiss S, Varghese R, Bauer K, Szebenyi C, Kocsube S, Homa M . Characterization of Three Pleiotropic Drug Resistance Transporter Genes and Their Participation in the Azole Resistance of . Front Cell Infect Microbiol. 2021; 11:660347. PMC: 8079984. DOI: 10.3389/fcimb.2021.660347. View

Inglesfield S, Jasiulewicz A, Hopwood M, Tyrrell J, Youlden G, Mazon-Moya M . Robust Phagocyte Recruitment Controls the Opportunistic Fungal Pathogen in Innate Granulomas . mBio. 2018; 9(2). PMC: 5874920. DOI: 10.1128/mBio.02010-17. View

Wurster S, Tatara A, Albert N, Ibrahim A, Heitman J, Lee S . Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds. mBio. 2020; 11(3). PMC: 7327176. DOI: 10.1128/mBio.01414-20. View

Hussain S, Riad A, Singh A, Klugarova J, Antony B, Banna H . Global Prevalence of COVID-19-Associated Mucormycosis (CAM): Living Systematic Review and Meta-Analysis. J Fungi (Basel). 2021; 7(11). PMC: 8624337. DOI: 10.3390/jof7110985. View

Lee S, Li A, Calo S, Inoue M, Tonthat N, Bain J . Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. Mol Microbiol. 2015; 97(5):844-65. PMC: 4633022. DOI: 10.1111/mmi.13071. View

Szebenyi C, Gu Y, Gebremariam T, Kocsube S, Kiss-Vetrab S, Jager O . Genes Are Necessary for Normal Spore Formation and Virulence in . mBio. 2023; 14(1):e0338622. PMC: 9973265. DOI: 10.1128/mbio.03386-22. View

Torres-Martinez S, Ruiz-Vazquez R . RNAi pathways in Mucor: A tale of proteins, small RNAs and functional diversity. Fungal Genet Biol. 2015; 90:44-52. DOI: 10.1016/j.fgb.2015.11.006. View

Soliman S, El-Labbad E, Abu-Qiyas A, Fayed B, Hamoda A, Al-Rawi A . Novel Secreted Peptides From var. With Immunomodulatory Effects That Enhance Fungal Pathogenesis. Front Microbiol. 2022; 13:863133. PMC: 8977774. DOI: 10.3389/fmicb.2022.863133. View

Jeong W, Keighley C, Wolfe R, Lee W, Slavin M, Chen S . Contemporary management and clinical outcomes of mucormycosis: A systematic review and meta-analysis of case reports. Int J Antimicrob Agents. 2019; 53(5):589-597. DOI: 10.1016/j.ijantimicag.2019.01.002. View

10.

Lee S, Li A, Calo S, Heitman J . Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides. PLoS Pathog. 2013; 9(9):e1003625. PMC: 3764228. DOI: 10.1371/journal.ppat.1003625. View

11.

Perez-Arques C, Navarro-Mendoza M, Murcia L, Lax C, Martinez-Garcia P, Heitman J . Thrives inside the Phagosome through an Atf-Mediated Germination Pathway. mBio. 2019; 10(1). PMC: 6428757. DOI: 10.1128/mBio.02765-18. View

12.

Diaz-Perez S, Patino-Medina J, Valle-Maldonado M, Lopez-Torres A, Jacome-Galarza I, Anaya-Martinez V . Alteration of Fermentative Metabolism Enhances Mucor circinelloides Virulence. Infect Immun. 2019; 88(2). PMC: 6977124. DOI: 10.1128/IAI.00434-19. View

13.

Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman G . COVID-19-associated fungal infections. Nat Microbiol. 2022; 7(8):1127-1140. PMC: 9362108. DOI: 10.1038/s41564-022-01172-2. View

14.

Valle-Maldonado M, Patino-Medina J, Perez-Arques C, Reyes-Mares N, Jacome-Galarza I, Ortiz-Alvarado R . The heterotrimeric G-protein beta subunit Gpb1 controls hyphal growth under low oxygen conditions through the protein kinase A pathway and is essential for virulence in the fungus Mucor circinelloides. Cell Microbiol. 2020; 22(10):e13236. DOI: 10.1111/cmi.13236. View

15.

Itabangi H, Sephton-Clark P, Tamayo D, Zhou X, Starling G, Mahamoud Z . A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence. Curr Biol. 2022; 32(5):1115-1130.e6. PMC: 8926845. DOI: 10.1016/j.cub.2022.01.028. View

16.

Alejandre-Castaneda V, Patino-Medina J, Valle-Maldonado M, Nunez-Anita R, Santoyo G, Castro-Cerritos K . Secretion of the siderophore rhizoferrin is regulated by the cAMP-PKA pathway and is involved in the virulence of Mucor lusitanicus. Sci Rep. 2022; 12(1):10649. PMC: 9226013. DOI: 10.1038/s41598-022-14515-0. View

17.

Ghosh A, Sarkar A, Paul P, Patel P . The rise in cases of mucormycosis, candidiasis and aspergillosis amidst COVID19. Fungal Biol Rev. 2021; 38:67-91. PMC: 8445778. DOI: 10.1016/j.fbr.2021.09.003. View

18.

Chang Z, Heitman J . Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides. mBio. 2019; 10(6). PMC: 6831780. DOI: 10.1128/mBio.02579-19. View

19.

Calo S, Shertz-Wall C, Lee S, Bastidas R, Nicolas F, Granek J . Antifungal drug resistance evoked via RNAi-dependent epimutations. Nature. 2014; 513(7519):555-8. PMC: 4177005. DOI: 10.1038/nature13575. View

20.

Nicolas F, Navarro-Mendoza M, Perez-Arques C, Lopez-Garcia S, Navarro E, Torres-Martinez S . Molecular Tools for Carotenogenesis Analysis in the Mucoral Mucor circinelloides. Methods Mol Biol. 2018; 1852:221-237. DOI: 10.1007/978-1-4939-8742-9_13. View