Network Pharmacology Implicates Traditional Chinese Medicine in Regulating Systemic Homeostasis to Benefit Alzheimer's Disease

Overview

Journal Tzu Chi Med J

Specialty General Medicine

Date 2023 Jun 1

PMID 37261294

Authors

Sheng-Tzung Tsai

Hsin-Yi Huang

Affiliations

Soon will be listed here.

Abstract

Traditional Chinese medicine (TCM) has the characteristics of multi-component, multi-target, and biological systems coordination, which meet the criteria of the network pharmacological application. Therefore, using network pharmacology to discover the relationship between TCM, diseases, and cellular responses is easily achievable. Aging-induced imbalanced homeostasis is a risk factor for Alzheimer's disease (AD), a neuronal disease regulated by multiple genes. Meta-analysis of TCM in metabolic regulation to improve symptoms of AD helps understand the pharmacological effects. The drug targets of TCM can be investigated using a holistic network pharmacology approach to find potential modulators involved in AD-related metabolic pathways. Based on the theoretical prediction of TCM for AD, experimental validation is needed to develop pure compounds for specific treatments.

References

Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J . The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020; 11(1):319. PMC: 6965647. DOI: 10.1038/s41467-019-14082-5. View

Matsuo H, Takada T, Nakayama A, Shimizu T, Sakiyama M, Shimizu S . ABCG2 dysfunction increases the risk of renal overload hyperuricemia. Nucleosides Nucleotides Nucleic Acids. 2014; 33(4-6):266-74. DOI: 10.1080/15257770.2013.866679. View

Salehi B, Venditti A, Sharifi-Rad M, Kregiel D, Sharifi-Rad J, Durazzo A . The Therapeutic Potential of Apigenin. Int J Mol Sci. 2019; 20(6). PMC: 6472148. DOI: 10.3390/ijms20061305. View

Gao L, Zhang Y, Cui Y, Akinyi O . Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6. Evid Based Complement Alternat Med. 2015; 2015:470219. PMC: 4452296. DOI: 10.1155/2015/470219. View

Jiang Y, Guo Y, Lu D, Pan M, Liu H, Jiao G . Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation. J Ethnopharmacol. 2020; 256:112824. DOI: 10.1016/j.jep.2020.112824. View

Wang X, Sun T, Li Y, Wang Y, Li Y, Yang L . A novel thiazolidinediones ATZD2 rescues memory deficits in a rat model of type 2 diabetes through antioxidant and antiinflammation. Oncotarget. 2018; 8(64):107409-107422. PMC: 5746076. DOI: 10.18632/oncotarget.22467. View

Khan H, Ullah H, Aschner M, Cheang W, Akkol E . Neuroprotective Effects of Quercetin in Alzheimer's Disease. Biomolecules. 2020; 10(1). PMC: 7023116. DOI: 10.3390/biom10010059. View

Wang J, Gu B, Masters C, Wang Y . A systemic view of Alzheimer disease - insights from amyloid-β metabolism beyond the brain. Nat Rev Neurol. 2017; 13(10):612-623. DOI: 10.1038/nrneurol.2017.111. View

Muddapu V, Dharshini S, Chakravarthy V, Gromiha M . Neurodegenerative Diseases - Is Metabolic Deficiency the Root Cause?. Front Neurosci. 2020; 14:213. PMC: 7137637. DOI: 10.3389/fnins.2020.00213. View

10.

Kurochkin I, Guarnera E, Berezovsky I . Insulin-Degrading Enzyme in the Fight against Alzheimer's Disease. Trends Pharmacol Sci. 2017; 39(1):49-58. DOI: 10.1016/j.tips.2017.10.008. View

11.

Tzikas S, Schlak D, Sopova K, Gatsiou A, Stakos D, Stamatelopoulos K . Increased myeloperoxidase plasma levels in patients with Alzheimer's disease. J Alzheimers Dis. 2013; 39(3):557-64. DOI: 10.3233/JAD-131469. View

12.

Hsu W, Shen Y, Shiao Y, Kuo C, Lu C, Lin T . Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease. PLoS One. 2019; 14(1):e0209184. PMC: 6333407. DOI: 10.1371/journal.pone.0209184. View

13.

Huang J, Wang X, Xie L, Wu M, Zhao W, Zhang Y . Extract of Danggui-Shaoyao-San ameliorates cognition deficits by regulating DHA metabolism in APP/PS1 mice. J Ethnopharmacol. 2020; 253:112673. DOI: 10.1016/j.jep.2020.112673. View

14.

Wu Q, Chen Y, Gu Y, Fang S, Li W, Wang Q . Systems pharmacology-based approach to investigate the mechanisms of Danggui-Shaoyao-san prescription for treatment of Alzheimer's disease. BMC Complement Med Ther. 2020; 20(1):282. PMC: 7501700. DOI: 10.1186/s12906-020-03066-4. View

15.

Deng L, Li L, Zhai Y, Michael S, Yang C, Guo R . Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats. Evid Based Complement Alternat Med. 2020; 2020:3439191. PMC: 7593748. DOI: 10.1155/2020/3439191. View

16.

Deng L, Liu W, Xu Q, Guo R, Zhang D, Ni J . Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti-hypertension effect. Biomed Pharmacother. 2021; 145:112383. DOI: 10.1016/j.biopha.2021.112383. View

17.

Song Z, Li F, He C, Yu J, Li P, Li Z . In-depth transcriptomic analyses of LncRNA and mRNA expression in the hippocampus of APP/PS1 mice by Danggui-Shaoyao-San. Aging (Albany NY). 2020; 12(23):23945-23959. PMC: 7762474. DOI: 10.18632/aging.104068. View

18.

Wang L, Waltenberger B, Pferschy-Wenzig E, Blunder M, Liu X, Malainer C . Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochem Pharmacol. 2014; 92(1):73-89. PMC: 4212005. DOI: 10.1016/j.bcp.2014.07.018. View

19.

Yi M, Zhang C, Zhang Z, Yi P, Xu P, Huang J . Integrated Metabolomic and Lipidomic Analysis Reveals the Neuroprotective Mechanisms of Bushen Tiansui Formula in an A1-42-Induced Rat Model of Alzheimer's Disease. Oxid Med Cell Longev. 2020; 2020:5243453. PMC: 7322593. DOI: 10.1155/2020/5243453. View

20.

Wojtowicz S, Strosznajder A, Jezyna M, Strosznajder J . The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders. Neurochem Res. 2020; 45(5):972-988. PMC: 7162839. DOI: 10.1007/s11064-020-02993-5. View