An Adult Case of Adenovirus-Associated Acute Disseminated Encephalomyelitis

Overview

Journal Case Rep Infect Dis

Publisher Wiley

Specialty Infectious Diseases

Date 2023 Jun 1

PMID 37261248

Authors

Dewayne Campbell

Gordon S Wong

Hyun Park

Gavin McLeod

Affiliations

Soon will be listed here.

Abstract

Acute disseminated encephalomyelitis (ADEM) is an autoimmune neurological disease that predominately affects pediatric population. Only a single fatal adult case of adenovirus-associated ADEM has previously been published by Qamar et al. in 2021. Here, we present an adult case of adenovirus-associated ADEM, which was diagnosed early in her clinical course. The patient was treated with the prompt initiation of steroids, intravenous immune globulin (IVIG), and plasmapheresis (PLEX), and the patient recovered fully. This case highlights the importance of early accurate diagnosis for other clinicians to treat adenovirus-associated ADEM in a timely fashion to prevent a potentially fatal outcome.

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References

Koelman D, Mateen F . Acute disseminated encephalomyelitis: current controversies in diagnosis and outcome. J Neurol. 2015; 262(9):2013-24. DOI: 10.1007/s00415-015-7694-7. View

Pohl D, Alper G, Van Haren K, Kornberg A, Lucchinetti C, Tenembaum S . Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome. Neurology. 2016; 87(9 Suppl 2):S38-45. DOI: 10.1212/WNL.0000000000002825. View

Marchioni E, Ravaglia S, Montomoli C, Tavazzi E, Minoli L, Baldanti F . Postinfectious neurologic syndromes: a prospective cohort study. Neurology. 2013; 80(10):882-9. DOI: 10.1212/WNL.0b013e3182840b95. View

Weinshenker B, OBrien P, Petterson T, Noseworthy J, Lucchinetti C, Dodick D . A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann Neurol. 1999; 46(6):878-86. DOI: 10.1002/1531-8249(199912)46:6<878::aid-ana10>3.0.co;2-q. View

Winters J . Plasma exchange: concepts, mechanisms, and an overview of the American Society for Apheresis guidelines. Hematology Am Soc Hematol Educ Program. 2012; 2012:7-12. DOI: 10.1182/asheducation-2012.1.7. View

Feasby T, Banwell B, Benstead T, Bril V, Brouwers M, Freedman M . Guidelines on the use of intravenous immune globulin for neurologic conditions. Transfus Med Rev. 2007; 21(2 Suppl 1):S57-107. DOI: 10.1016/j.tmrv.2007.01.002. View

Wy Ip W, Qasim W . Management of adenovirus in children after allogeneic hematopoietic stem cell transplantation. Adv Hematol. 2013; 2013:176418. PMC: 3830830. DOI: 10.1155/2013/176418. View

Vitaliti G, Tabatabaie O, Matin N, Ledda C, Pavone P, Lubrano R . The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data. Hum Vaccin Immunother. 2015; 11(12):2749-63. PMC: 5391617. DOI: 10.1080/21645515.2015.1061161. View

Xiong C, Yan Y, Liao Z, Peng S, Wen H, Zhang Y . Epidemiological characteristics of acute disseminated encephalomyelitis in Nanchang, China: a retrospective study. BMC Public Health. 2014; 14:111. PMC: 3922734. DOI: 10.1186/1471-2458-14-111. View

10.

Deng S, Qiu K, Tu R, Zheng H, Lu W . Relationship Between Pregnancy and Acute Disseminated Encephalomyelitis: A Single-Case Study. Front Immunol. 2021; 11:609476. PMC: 7882727. DOI: 10.3389/fimmu.2020.609476. View

11.

Qamar Z, Tucker C, Kenyon L, Royer T . A rare fatal case of adenovirus serotype 4 associated acute disseminated encephalomyelitis in an adult: A case report. IDCases. 2021; 25:e01213. PMC: 8267438. DOI: 10.1016/j.idcr.2021.e01213. View

12.

Almaghrabi N, Saab A . Adult onset acute disseminated encephalomyelitis: A case report. Radiol Case Rep. 2021; 16(9):2469-2473. PMC: 8260756. DOI: 10.1016/j.radcr.2021.05.052. View

13.

Ayed H, Chaudhary M, Albaradie R, Mir A . Use of Cyclophosphamide in a Child With Fulminant Acute Disseminated Encephalomyelitis. Child Neurol Open. 2018; 5:2329048X18754631. PMC: 5851101. DOI: 10.1177/2329048X18754631. View

14.

Pohl D, Tenembaum S . Treatment of acute disseminated encephalomyelitis. Curr Treat Options Neurol. 2012; 14(3):264-75. DOI: 10.1007/s11940-012-0170-0. View

15.

Koelman D, Chahin S, Mar S, Venkatesan A, Hoganson G, Yeshokumar A . Acute disseminated encephalomyelitis in 228 patients: A retrospective, multicenter US study. Neurology. 2016; 86(22):2085-93. DOI: 10.1212/WNL.0000000000002723. View

16.

Wang C . Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient. Paediatr Drugs. 2021; 23(3):213-221. PMC: 8026386. DOI: 10.1007/s40272-021-00441-7. View

17.

Parsons T, Banks S, Bae C, Gelber J, Alahmadi H, Tichauer M . COVID-19-associated acute disseminated encephalomyelitis (ADEM). J Neurol. 2020; 267(10):2799-2802. PMC: 7260459. DOI: 10.1007/s00415-020-09951-9. View

18.

Ketelslegers I, Visser I, Neuteboom R, Boon M, Catsman-Berrevoets C, Hintzen R . Disease course and outcome of acute disseminated encephalomyelitis is more severe in adults than in children. Mult Scler. 2010; 17(4):441-8. DOI: 10.1177/1352458510390068. View

19.

Paolilo R, Deiva K, Neuteboom R, Rostasy K, Lim M . Acute Disseminated Encephalomyelitis: Current Perspectives. Children (Basel). 2020; 7(11). PMC: 7692206. DOI: 10.3390/children7110210. View

20.

Marin S, Callen D . The magnetic resonance imaging appearance of monophasic acute disseminated encephalomyelitis: an update post application of the 2007 consensus criteria. Neuroimaging Clin N Am. 2013; 23(2):245-66. PMC: 7111644. DOI: 10.1016/j.nic.2012.12.005. View