Accelerated High Frequency RTMS Induces Time-dependent Dopaminergic Alterations: a DaTSCAN Brain Imaging Study in Healthy Beagle Dogs

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2023 Jun 1

PMID 37261109

Authors

Yangfeng Xu

Kathelijne Peremans

Sofie Salden

Kurt Audenaert

Andre Dobbeleir

Ann Van Eeckhaut

Dimitri De Bundel

Jimmy H Saunders

Chris Baeken

Affiliations

Soon will be listed here.

Abstract

Aim: The neurobiological effects of repetitive transcranial magnetic stimulation are believed to run in part through the dopaminergic system. Accelerated high frequency rTMS (aHF-rTMS), a new form of stimuli delivery, is currently being tested for its usefulness in treating human and canine mental disorders. However, the short-and long-term neurobiological effects are still unclear, including the effects on the dopaminergic system. In aHF-rTMS, multiple sessions are delivered within 1 day instead of one session per day, not only to accelerate the time to response but also to increase clinical efficacy. To gain more insight into the neurobiology of aHF-rTMS, we investigated whether applying five sessions in 1 day has direct and/or delayed effects on the dopamine transporter (DAT), and on dopamine metabolites of cerebrospinal fluid (CSF) in beagles.

Materials And Methods: Thirteen beagles were randomly divided into two groups: five active stimulation sessions ( = 9), and 5 sham stimulation sessions ( = 4). Using DaTSCAN, DAT binding indices (BI) were obtained at baseline, after 1 day, 1 month, and 3 months post stimulation. CSF samples were collected after each scan.

Results: Active aHF-rTMS significantly reduced striatal DAT BI 1 day post-active stimulation session ( < 0.01), and the effect lasted to 1 month ( < 0.01). No significant DAT BI change was found in sham group. No significant changes in dopamine metabolites of CSF were found.

Conclusion: Although no significant effects on CSF dopamine metabolites were observed, five sessions of active aHF-rTMS significantly decreased striatal DAT BI after 1 day and up to 1 month post stimulation, indicating immediate and delayed effects on the brain dopaminergic system. Our findings in healthy beagles further substantiate the assumption that (a)HF-rTMS affects the brain dopaminergic system and it may pave the way to apply (a)HF-rTMS treatment in behaviorally disturbed dogs.

Citing Articles

Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder.

Di Carlo F, Pettorruso M, Santorelli M, Cocciolillo F, dAndrea G, Di Nicola M J Gambl Stud. 2024; 40(4):2189-2200.

PMID: 38755422 PMC: 11557681. DOI: 10.1007/s10899-024-10311-9.

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