Distinct Role of L. Polysaccharides in Oxidative Stress-Related Ocular Diseases

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2023 Jun 1

PMID 37259363

Authors

Yali Niu

Guoheng Zhang

Xiaojia Sun

Shikun He

Guorui Dou

Affiliations

Soon will be listed here.

Abstract

Oxidative stress is an imbalance between the increased production of reactive species and reduced antioxidant activity, which can cause a variety of disturbances including ocular diseases. polysaccharides (LBPs) are complex polysaccharides isolated from the fruit of , showing distinct roles in antioxidants. Moreover, it is relatively safe and non-toxic. In recent years, the antioxidant activities of LBPs have attracted remarkable attention. In order to illustrate its significance and underlying therapeutic value for vision, we comprehensively review the recent progress on the antioxidant mechanisms of LBP and its potential applications in ocular diseases, including diabetic retinopathy, hypertensive neuroretinopathy, age-related macular degeneration, retinitis pigmentosa, retinal ischemia/reperfusion injury, glaucoma, dry eye syndrome, and diabetic cataract.

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References

Yang F, Wei Y, Liao B, Wei G, Qin H, Pang X . Effects of Polysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice. Front Pharmacol. 2020; 11:742. PMC: 7264112. DOI: 10.3389/fphar.2020.00742. View

Wang Z, Sun Q, Fang J, Wang C, Wang D, Li M . The anti-aging activity of Lycium barbarum polysaccharide extracted by yeast fermentation: In vivo and in vitro studies. Int J Biol Macromol. 2022; 209(Pt B):2032-2041. DOI: 10.1016/j.ijbiomac.2022.04.184. View

McMonnies C . Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy. J Optom. 2017; 11(1):3-9. PMC: 5777925. DOI: 10.1016/j.optom.2017.06.002. View

Li X . Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int J Biol Macromol. 2006; 40(5):461-5. DOI: 10.1016/j.ijbiomac.2006.11.002. View

Hsieh F, Hung C, Cheng K, Wu C, Chen Y, Wu Y . Protective Effects of Extracts on UVB-Induced Damage in Human Retinal Pigment Epithelial Cells Accompanied by Attenuating ROS and DNA Damage. Oxid Med Cell Longev. 2018; 2018:4814928. PMC: 6247443. DOI: 10.1155/2018/4814928. View

Kratochvilova K, Moran L, Padourova S, Stejskal S, Tesarova L, Simara P . The role of the endoplasmic reticulum stress in stemness, pluripotency and development. Eur J Cell Biol. 2016; 95(3-5):115-23. DOI: 10.1016/j.ejcb.2016.02.002. View

Chan H, Lam H, Choi K, Li S, Lakshmanan Y, Yu W . Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement. J Ethnopharmacol. 2019; 236:336-344. DOI: 10.1016/j.jep.2019.03.023. View

Li H, Ruan Y, Kau P, Chiu K, Chang R, Chan H . Effect of Lycium barbarum (Wolfberry) on alleviating axonal degeneration after partial optic nerve transection. Cell Transplant. 2015; 24(3):403-17. DOI: 10.3727/096368915X686896. View

Wu J, Kosten T, Zhang X . Free radicals, antioxidant defense systems, and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2013; 46:200-6. DOI: 10.1016/j.pnpbp.2013.02.015. View

10.

Stitt A, Curtis T, Chen M, Medina R, Mckay G, Jenkins A . The progress in understanding and treatment of diabetic retinopathy. Prog Retin Eye Res. 2015; 51:156-86. DOI: 10.1016/j.preteyeres.2015.08.001. View

11.

Vujosevic S, Aldington S, Silva P, Hernandez C, Scanlon P, Peto T . Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol. 2020; 8(4):337-347. DOI: 10.1016/S2213-8587(19)30411-5. View

12.

Pan H, Shi Z, Yang T, Yu L, Xu A . [The protective effects of lycium barbarum polysaccharides on retinal neurons in diabetic rats and its mechanism]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019; 35(1):55-59. DOI: 10.12047/j.cjap.5706.2019.014. View

13.

Yang D, So K, Lo A . Lycium barbarum polysaccharide extracts preserve retinal function and attenuate inner retinal neuronal damage in a mouse model of transient retinal ischaemia. Clin Exp Ophthalmol. 2017; 45(7):717-729. DOI: 10.1111/ceo.12950. View

14.

Xia G, Xin N, Liu W, Yao H, Hou Y, Qi J . Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway. Mol Med Rep. 2014; 9(4):1237-41. DOI: 10.3892/mmr.2014.1964. View

15.

Yao Q, Zhou Y, Yang Y, Cai L, Xu L, Han X . Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract. J Ethnopharmacol. 2020; 261:113165. DOI: 10.1016/j.jep.2020.113165. View

16.

Tang L, Bao S, Du Y, Jiang Z, Wuliji A, Ren X . Antioxidant effects of Lycium barbarum polysaccharides on photoreceptor degeneration in the light-exposed mouse retina. Biomed Pharmacother. 2018; 103:829-837. DOI: 10.1016/j.biopha.2018.04.104. View

17.

Zaric B, Macvanin M, Isenovic E . Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. Int J Biochem Cell Biol. 2022; 154:106346. DOI: 10.1016/j.biocel.2022.106346. View

18.

Li Y, Yang B, Zhang X, Shen X, Ma Y, Jing L . Lycium barbarum polysaccharide antagonizes cardiomyocyte apoptosis by inhibiting the upregulation of GRK2 induced by I/R injury, and salvage mitochondrial fission/fusion imbalance and AKT/eNOS signaling. Cell Signal. 2022; 92:110252. DOI: 10.1016/j.cellsig.2022.110252. View

19.

Liu L, Lao W, Ji Q, Yang Z, Yu G, Zhong J . Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis. Int J Ophthalmol. 2015; 8(1):11-6. PMC: 4325234. DOI: 10.3980/j.issn.2222-3959.2015.01.02. View

20.

Hong C, Zhang H, Liu X, Xu Y . Attenuation of hyperoxic acute lung injury by Lycium barbarum polysaccharide via inhibiting NLRP3 inflammasome. Arch Pharm Res. 2019; 42(10):902-908. DOI: 10.1007/s12272-019-01175-4. View