Bulk and Single-cell Transcriptome Profiling Reveal the Metabolic Heterogeneity in Gastric Cancer

Overview

Journal Sci Rep

Specialty Science

Date 2023 May 31

PMID 37258571

Authors

Guoqiang Tao

Xiangyu Wen

Xingxing Wang

Qi Zhou

Affiliations

Soon will be listed here.

Abstract

Metabolic reprogramming has been defined as a key hall mark of human tumors. However, metabolic heterogeneity in gastric cancer has not been elucidated. Here we separated the TCGA-STAD dataset into two metabolic subtypes. The differences between subtypes were elaborated in terms of transcriptomics, genomics, tumor-infiltrating cells, and single-cell resolution. We found that metabolic subtype 1 is predominantly characterized by low metabolism, high immune cell infiltration. Subtype 2 is mainly characterized by high metabolism and low immune cell infiltration. From single-cell resolution, we found that the high metabolism of subtype 2 is dominated by epithelial cells. Not only epithelial cells, but also various immune cells and stromal cells showed high metabolism in subtype 2 and low metabolism in subtype 1. Our study established a classification of gastric cancer metabolic subtypes and explored the differences between subtypes from multiple dimensions, especially the single-cell resolution.

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