Research Progress on the E Protein of Porcine Reproductive and Respiratory Syndrome Virus

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2023 May 31

PMID 37256059

Authors

Xiuqiao Chen

Jinghua Pan

Liangzong Huang

Mengmeng Zhao

Affiliations

Soon will be listed here.

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease impacting the global pig industry, and it is characterized by reproductive disorder in sows and respiratory disorder in pigs of all ages. The PRRSV E protein is a nonglycosylated structural protein encoded by the ORF2b gene. The E protein is not necessary for the assembly of virus particles, but deletion of the E protein leads to transmissible virus particles not being produced. To better understand the structure and function of the E protein, we reviewed its genetic and evolutionary analysis, characteristics, subcellular localization and topology, ion channel activity, cellular immune response, additional biological functions, interactions with host proteins, interactions with PRRSV proteins, roles in infection, pathogenicity, and drugs. Therefore, this review can provide a theoretical basis for gaining an in-depth understanding of the E protein of PRRSV-2.

Citing Articles

Understanding Post-Translational Modifications in Porcine Reproductive and Respiratory Syndrome Virus Infection.

Chen X, Zhang J Vet Sci. 2024; 11(12).

PMID: 39728994 PMC: 11680304. DOI: 10.3390/vetsci11120654.

Mechanism of PRRSV infection and antiviral role of polyphenols.

Amona F, Pang Y, Gong X, Wang Y, Fang X, Zhang C Virulence. 2024; 15(1):2417707.

PMID: 39432383 PMC: 11497994. DOI: 10.1080/21505594.2024.2417707.

Identification and biophysical characterization of epitope atlas of Porcine Reproductive and Respiratory Syndrome Virus.

Dey S, Bruner J, Brown M, Roof M, Chowdhury R Comput Struct Biotechnol J. 2024; 23:3348-3357.

PMID: 39310279 PMC: 11416235. DOI: 10.1016/j.csbj.2024.08.029.

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