Primary Hyperparathyroidism Associated with Colorectal Cancer: Case Report

Overview

Journal J Surg Case Rep

Publisher Oxford University Press

Specialty General Surgery

Date 2023 May 30

PMID 37251246

Authors

Ahmed Y Al Ameer

Amirah Hassan Alqawba

Dalia Hamed Eid Alqarni

Reema Mesfer A Alsaluli

Adel Mohamed Aboregela

Saad A Alqarni

Affiliations

Soon will be listed here.

Abstract

The association between colorectal cancer and primary hyperparathyroidism has been reported as case reports in the literature. There are few data regarding the molecular explanation of such coexistence. Here we report a case with synchronous pathologies of primary hyperparathyroidism and colorectal cancer. Furthermore, the patient has a positive family history of the same two pathologies in one of his first-degree relatives. We reviewed the literature to clarify and explain the relationship between these two diseases. We aimed to shed light on the coexistence of such conditions and to clarify if there is a relation between them or if it is just a coincidence.

References

Blau J, Simonds W . Familial Hyperparathyroidism. Front Endocrinol (Lausanne). 2021; 12:623667. PMC: 7947864. DOI: 10.3389/fendo.2021.623667. View

Yu N, Donnan P, Murphy M, Leese G . Epidemiology of primary hyperparathyroidism in Tayside, Scotland, UK. Clin Endocrinol (Oxf). 2009; 71(4):485-93. DOI: 10.1111/j.1365-2265.2008.03520.x. View

Henry J, Defechereux T, Raffaelli M, Lubrano D, Iacobone M . [Supernumerary ectopic hyperfunctioning parathyroid gland: a potential pitfall in surgery for sporadic primary hyperthyroidism]. Ann Chir. 2000; 125(3):247-52. DOI: 10.1016/s0003-3944(00)00247-9. View

Felger E, Kandil E . Primary hyperparathyroidism. Otolaryngol Clin North Am. 2010; 43(2):417-32, x. DOI: 10.1016/j.otc.2010.01.009. View

Thakker R . Genetics of parathyroid tumours. J Intern Med. 2016; 280(6):574-583. DOI: 10.1111/joim.12523. View

Ammon H, Thomas P, Phillips S . Effects of oleic and ricinoleic acids on net jejunal water and electrolyte movement. Perfusion studies in man. J Clin Invest. 1974; 53(2):374-9. PMC: 301478. DOI: 10.1172/JCI107569. View

Marx S, Spiegel A, Levine M, Rizzoli R, Lasker R, Santora A . Familial hypocalciuric hypercalcemia: the relation to primary parathyroid hyperplasia. N Engl J Med. 1982; 307(7):416-26. DOI: 10.1056/NEJM198208123070707. View

Yeh M, Ituarte P, Zhou H, Nishimoto S, Liu I, Harari A . Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab. 2013; 98(3):1122-9. PMC: 3590475. DOI: 10.1210/jc.2012-4022. View

Newmark H, Wargovich M, Bruce W . Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. J Natl Cancer Inst. 1984; 72(6):1323-5. View

10.

Jackson C . Hereditary hyperparathyroidism associated with recurrent pancreatitis. Ann Intern Med. 1958; 49(4):829-36. DOI: 10.7326/0003-4819-49-4-829. View

11.

Kawamura Y, Kazama S, Miyahara T, Masaki T, Muto T . Sigmoid colon cancer associated with primary hyperparathyroidism: report of a case. Surg Today. 1999; 29(8):789-90. DOI: 10.1007/BF02482329. View

12.

Rawla P, Sunkara T, Barsouk A . Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019; 14(2):89-103. PMC: 6791134. DOI: 10.5114/pg.2018.81072. View

13.

Rothwell P, Wilson M, Elwin C, Norrving B, Algra A, Warlow C . Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 2010; 376(9754):1741-50. DOI: 10.1016/S0140-6736(10)61543-7. View

14.

Madkhali T, Alhefdhi A, Chen H, Elfenbein D . Primary hyperparathyroidism. Ulus Cerrahi Derg. 2016; 32(1):58-66. PMC: 4771429. DOI: 10.5152/UCD.2015.3032. View

15.

Berg J, Howell M, Silverman S . Dietary hypotheses and diet-related research in the etiology of colon cancer. Health Serv Rep. 1973; 88(10):915-24. PMC: 1616111. View

16.

Feig D, Gottesman I . Familial hyperparathyroidism in association with colonic carcinoma. Cancer. 1987; 60(3):429-32. DOI: 10.1002/1097-0142(19870801)60:3<429::aid-cncr2820600325>3.0.co;2-3. View

17.

Tzikos G, Polyzonis M, Milias K, Milias S, Passos I, Ioannidis K . Double ipsilateral parathyroid adenomas, with one supernumerary and ectopic at the same time: a case report. J Med Case Rep. 2021; 15(1):198. PMC: 8042868. DOI: 10.1186/s13256-021-02711-x. View

18.

Afreen S, Weinstein L, Simonds W, Jha S . Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer. J Endocr Soc. 2022; 6(8):bvac096. PMC: 9261500. DOI: 10.1210/jendso/bvac096. View