Is Space Flight Arrhythmogenic?

Overview

Journal Front Physiol

Date 2023 May 30

PMID 37250132

Authors

O V Popova

V B Rusanov

Affiliations

Soon will be listed here.

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References

Koenig J, Thayer J . Sex differences in healthy human heart rate variability: A meta-analysis. Neurosci Biobehav Rev. 2016; 64:288-310. DOI: 10.1016/j.neubiorev.2016.03.007. View

Garrett-Bakelman F, Darshi M, Green S, Gur R, Lin L, Macias B . The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019; 364(6436). PMC: 7580864. DOI: 10.1126/science.aau8650. View

Guo J, Qu W, Chen S, Chen X, Lv K, Huang Z . Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts. Mil Med Res. 2015; 1:23. PMC: 4440601. DOI: 10.1186/2054-9369-1-23. View

Leach C, ALFREY C, Suki W, Leonard J, Rambaut P, Inners L . Regulation of body fluid compartments during short-term spaceflight. J Appl Physiol (1985). 1996; 81(1):105-16. DOI: 10.1152/jappl.1996.81.1.105. View

DSouza A, Trussell T, Morris G, Dobrzynski H, Boyett M . Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions. Physiology (Bethesda). 2019; 34(5):314-326. DOI: 10.1152/physiol.00009.2019. View

Dijk D, Neri D, Wyatt J, Ronda J, Riel E, Hughes R . Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights. Am J Physiol Regul Integr Comp Physiol. 2001; 281(5):R1647-64. DOI: 10.1152/ajpregu.2001.281.5.R1647. View

Soucy K, Lim H, Kim J, Oh Y, Attarzadeh D, Sevinc B . HZE ⁵⁶Fe-ion irradiation induces endothelial dysfunction in rat aorta: role of xanthine oxidase. Radiat Res. 2011; 176(4):474-85. DOI: 10.1667/rr2598.1. View

Kumei Y, Shimokawa H, Katano H, Akiyama H, Hirano M, Mukai C . Spaceflight modulates insulin-like growth factor binding proteins and glucocorticoid receptor in osteoblasts. J Appl Physiol (1985). 1998; 85(1):139-47. DOI: 10.1152/jappl.1998.85.1.139. View

Delp M, Charvat J, Limoli C, Globus R, Ghosh P . Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium. Sci Rep. 2016; 6:29901. PMC: 4964660. DOI: 10.1038/srep29901. View

10.

Meerman M, Bracco Gartner T, Buikema J, Wu S, Siddiqi S, Bouten C . Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem. Front Cardiovasc Med. 2021; 8:631985. PMC: 7906998. DOI: 10.3389/fcvm.2021.631985. View

11.

Leuenberger U, DAunno D, Rossum A, Brown T, Wood M, Josephson M . An episode of ventricular tachycardia during long-duration spaceflight. Am J Cardiol. 1998; 81(11):1391-2. DOI: 10.1016/s0002-9149(98)00179-9. View

12.

King D, Entz 2nd M, Blair G, Crandell I, Hanlon A, Lin J . The conduction velocity-potassium relationship in the heart is modulated by sodium and calcium. Pflugers Arch. 2021; 473(3):557-571. PMC: 7940307. DOI: 10.1007/s00424-021-02537-y. View

13.

Chow G, Marine J, Fleg J . Epidemiology of arrhythmias and conduction disorders in older adults. Clin Geriatr Med. 2012; 28(4):539-53. PMC: 3483564. DOI: 10.1016/j.cger.2012.07.003. View

14.

Khine H, Steding-Ehrenborg K, Hastings J, Kowal J, Daniels J, Page R . Effects of Prolonged Spaceflight on Atrial Size, Atrial Electrophysiology, and Risk of Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2018; 11(5):e005959. DOI: 10.1161/CIRCEP.117.005959. View

15.

Ramadan S, Sridharan V, Koturbash I, Miousse I, Hauer-Jensen M, Nelson G . A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation. Life Sci Space Res (Amst). 2016; 8:8-13. PMC: 4782196. DOI: 10.1016/j.lssr.2015.12.001. View

16.

Gontcharov I, Kovachevich I, Pool S, Navinkov O, Barratt M, Bogomolov V . In-flight medical incidents in the NASA-Mir program. Aviat Space Environ Med. 2005; 76(7):692-6. View

17.

Perhonen M, Franco F, Lane L, Buckey J, Blomqvist C, Zerwekh J . Cardiac atrophy after bed rest and spaceflight. J Appl Physiol (1985). 2001; 91(2):645-53. DOI: 10.1152/jappl.2001.91.2.645. View

18.

Kozlovskaya I, Yarmanova E, Fomina E . [Russian system of countermeasures: the present and future]. Aviakosm Ekolog Med. 2013; 47(1):13-20. View

19.

Shen M, Frishman W . Effects of Spaceflight on Cardiovascular Physiology and Health. Cardiol Rev. 2018; 27(3):122-126. DOI: 10.1097/CRD.0000000000000236. View

20.

Rossum A, Wood M, Bishop S, Deblock H, Charles J . Evaluation of cardiac rhythm disturbances during extravehicular activity. Am J Cardiol. 1997; 79(8):1153-5. DOI: 10.1016/s0002-9149(97)00071-4. View