Survival Benefit of Radiotherapy and Nomogram for Patients with Primary Tracheal Malignant Tumors: a Propensity Score-matched SEER Database Analysis

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2023 May 30

PMID 37249645

Authors

Zhen Zheng

Zhennan Du

Zhongjie Fang

Yunbin Shi

Xue Chen

Ming Jin

Kaitai Liu

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of this study was to conduct a matched-pair analysis to assess the impact of radiotherapy (RT) on patients with malignant tracheal tumors using the surveillance, epidemiology, and end results database. Additionally, a predictive nomogram was developed for patients with malignant tracheal tumors.

Methods: Propensity score matching (PSM) was used to minimize bias between the RT and no-RT groups. We utilized both univariate and multivariate Cox proportional hazards regression analyses to identify independent prognostic factors for patients and subgroups. We developed a novel nomogram and evaluated its results using the C-index.

Results: A total of 648 patients between 1975 and 2019 were included, and 160 patients in RT were 1:1 propensity score-matched with no-RT. The independent prognostic factors for patients with tracheal malignant tumors were surgery, marital status, disease extension, pathology, and age. The independent risk factors for patients without surgery included RT and disease extension. The C-index confirmed that the nomogram accurately predicted the prognosis of patients with tracheal malignant tumors.

Conclusions: Our findings suggest that RT may provide a survival benefit for tracheal cancer patients who did not undergo surgery. The nomogram can be a useful tool for predicting prognosis in patients with tracheal malignant tumors.

Citing Articles

Treatment outcomes of patients with primary tracheal tumors - analysis of a large retrospective series.

Piorek A, Pluzanski A, Knetki-Wroblewska M, Winiarczyk K, Tabor S, Teterycz P BMC Cancer. 2024; 24(1):686.

PMID: 38840114 PMC: 11155021. DOI: 10.1186/s12885-024-12450-z.

Molecular Biology and Therapeutic Targets of Primitive Tracheal Tumors: Focus on Tumors Derived by Salivary Glands and Squamous Cell Carcinoma.

Marchioni A, Tonelli R, Samarelli A, Cappiello G, Andreani A, Tabbi L Int J Mol Sci. 2023; 24(14).

PMID: 37511133 PMC: 10379311. DOI: 10.3390/ijms241411370.

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