β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 May 27

PMID 37243289

Authors

Guolei Wang

Zhiqiang Li

Mingfu Tian

Xianghua Cui

June Ma

Siyu Liu

Chenglin Ye

Li Yuan

Muhammad Suhaib Qudus

Uzair Afaq

Kailang Wu

Xinghui Liu

Chengliang Zhu

Affiliations

Soon will be listed here.

Abstract

Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming. However, it is unclear whether β-glucan plays a role in antiviral infection. Therefore, this study investigated the role of trained immunity induced by and β-glucan in antiviral innate immunity. It showed that and β-glucan promoted the expression of interferon-β (IFN-β) and interleukin-6 (IL-6) in mouse macrophages triggered by viral infection. In addition, β-glucan pretreatment attenuated the pathological damage induced by the virus in mouse lungs and promoted the expression of IFN-β. Mechanistically, β-glucan could promote the phosphorylation and ubiquitination of TANK Binding Kinase 1 (TBK1), a key protein of the innate immune pathway. These results suggest that β-glucan can promote innate antiviral immunity, and this bioactive material may be a potential therapeutic target for antiviral treatment.

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