Effect of Vaccination on Platelet Mitochondrial Bioenergy Function of Patients with Post-Acute COVID-19

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 May 27

PMID 37243171

Authors

Anna Gvozdjakova

Jarmila Kucharska

Zuzana Rausova

Guillermo Lopez-Lluch

Placido Navas

Patrik Palacka

Barbora Bartolcicova

Zuzana Sumbalova

Affiliations

Soon will be listed here.

Abstract

Background: Mitochondrial dysfunction and redox cellular imbalance indicate crucial function in COVID-19 pathogenesis. Since 11 March 2020, a global pandemic, health crisis and economic disruption has been caused by SARS-CoV-2 virus. Vaccination is considered one of the most effective strategies for preventing viral infection. We tested the hypothesis that preventive vaccination affects the reduced bioenergetics of platelet mitochondria and the biosynthesis of endogenous coenzyme Q (CoQ) in patients with post-acute COVID-19.

Material And Methods: 10 vaccinated patients with post-acute COVID-19 (V + PAC19) and 10 unvaccinated patients with post-acute COVID-19 (PAC19) were included in the study. The control group (C) consisted of 16 healthy volunteers. Platelet mitochondrial bioenergy function was determined with HRR method. CoQ, γ-tocopherol, α-tocopherol and β-carotene were determined by HPLC, TBARS (thiobarbituric acid reactive substances) were determined spectrophotometrically.

Results: Vaccination protected platelet mitochondrial bioenergy function but not endogenous CoQ levels, in patients with post-acute COVID-19.

Conclusions: Vaccination against SARS-CoV-2 virus infection prevented the reduction of platelet mitochondrial respiration and energy production. The mechanism of suppression of CoQ levels by SARS-CoV-2 virus is not fully known. Methods for the determination of CoQ and HRR can be used for monitoring of mitochondrial bioenergetics and targeted therapy of patients with post-acute COVID-19.

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